Clidinium bromide

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Clidinium bromide
Clidinium bromide.svg
Clinical data
AHFS/Drugs.com Monograph
MedlinePlus a601036
Routes of
administration 		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability Low
Excretion Renal and biliary
Identifiers
  • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C22H26NO3+
Molar mass 352.454 g·mol−1
3D model (JSmol)
  • O=C(OC2C1CC[N+](CC1)(C)C2)C(O)(c3ccccc3)c4ccccc4
  • InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1 Yes check.svgY
  • Key:HOOSGZJRQIVJSZ-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Clidinium bromide (INN) is an anticholinergic (specifically a muscarinic antagonist) drug. [1] [2] It may help symptoms of cramping and abdominal/stomach pain by decreasing stomach acid, and slowing the intestines. It is commonly prescribed in combination with chlordiazepoxide (a benzodiazepine derivative) using the brand name Librax,Normaxin CC.

Contents

Uses

Peptic ulcer disease

Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers. [3]

With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.

GI motility disturbances

Used in fixed combination with chlordiazepoxide in the treatment of functional GI motility disturbances (e.g., irritable bowel syndrome).

Has limited efficacy in treatment of GI motility disturbance and should only be used if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.

Acute enterocolitis

Used in fixed combination with chlordiazepoxide in the treatment of acute enterocolitis. However, antimuscarinics should be used with extreme caution in patients with diarrhea or ulcerative colitis.

Mechanism of action

Clidinium inhibits muscarinic acetylcholine receptors on smooth muscles, secretory glands, and in the central nervous system to relax smooth muscle and decrease biliary tract secretions. [4] It is said to be a selective muscarinic acetylcholine M3 receptor antagonist. [5]

References

  1. ↑ "Clidinium bromide". Drugs.com. Retrieved August 24, 2013.
  2. ↑ Aronson JK (2016). "Clidinium bromide". Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions (Sixteenth ed.). Amsterdam: Elsevier. p. 404. ISBN   978-0-444-53716-4.
  3. ↑ "Clidinium Bromide Monograph". Drugs.com. Retrieved August 24, 2013.
  4. ↑ "Clidinium bromide". 2014 Nurse's Drug Handbook (13th ed.). Burlington, MA: Jones & Bartlett Learning. 2013. pp. 245–246. ISBN   978-1-284-03115-7.
  5. ↑ Lavrador M, Cabral AC, Veríssimo MT, Fernandez-Llimos F, Figueiredo IV, Castel-Branco MM (January 2023). "A Universal Pharmacological-Based List of Drugs with Anticholinergic Activity". Pharmaceutics. 15 (1): 230. doi: 10.3390/pharmaceutics15010230 . PMC   9863833 . PMID   36678858.
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