Tofenacin

Tofenacin

Clinical data
Trade names	Elamol, Tofacine, Tofalin
Other names	tofenacin hydrochloride (USAN US)
Routes of administration	By mouth
ATC code	None
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name N-methyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine
CAS Number	15301-93-6 10488-36-5 (HCl)
PubChem CID	25315
ChemSpider	23647
UNII	C4A112M10H
CompTox Dashboard (EPA)	DTXSID50864578
ECHA InfoCard	100.035.746
Chemical and physical data
Formula	C17H21NO
Molar mass	255.361 g·mol−1
3D model (JSmol)	Interactive image
SMILES O(CCNC)C(c1ccccc1)c2ccccc2C
InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)17(19-13-12-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3 Key:PNYKGCPSFKLFKA-UHFFFAOYSA-N

Tofenacin is an antidepressant drug with a tricyclic-like structure which was developed and marketed in the United Kingdom and Italy in 1971 and 1981, respectively, by Brocades-Stheeman & Pharmacia (now part of Astellas Pharma). ^{[1] [2] [3]} It acts as a serotonin-norepinephrine reuptake inhibitor, ^[4] and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients. ^{[5] [6]}

See also

• Clemastine
• Orphenadrine
• Tiazesim

References

1. Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 1041. ISBN   978-3-88763-075-1 . Retrieved 19 May 2012.
2. Buckingham J (1996). Dictionary of organic compounds: Chemical Abstracts Service registry number index. CRC Press. p. 6074. ISBN   978-0-412-54090-5 . Retrieved 19 May 2012.
3. Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Elsevier. 2013-01-15. p. 3268. ISBN   978-0-8155-1526-5 . Retrieved 19 May 2012.
4. van Dijk J, Hartog J, Hillen FC (1 January 1978). "Non-Tricyclic Antidepressants". In Ellis GP, West GB (eds.). Progress in Medicinal Chemistry. Elsevier. p. 284. ISBN   978-0-7204-0655-9 . Retrieved 19 May 2012.
5. Capstick N, Pudney H (1976). "A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy". The Journal of International Medical Research. 4 (6): 435–440. doi:10.1177/030006057600400610. PMID   800383. S2CID   40083513.
6. Altamura AC, Mauri MC, De Novellis F, Percudani M, Vampini V (November 1989). "Residual neuroleptic-induced parkinsonian symptoms in schizophrenia. A naturalistic study with orphenadrine". Pharmacopsychiatry. 22 (6): 246–249. doi:10.1055/s-2007-1014608. PMID   2616635. S2CID   39693625.