Caramiphen

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Caramiphen
Caramiphen.svg
Clinical data
Trade names Carafen
ATC code
  • None
Identifiers
  • 2-(Diethylamino)ethyl 1-phenylcyclopentanecarboxylate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.922 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C18H27NO2
Molar mass 289.419 g·mol−1
3D model (JSmol)
  • O=C(OCCN(CC)CC)C2(c1ccccc1)CCCC2
  • InChI=1S/C18H27NO2/c1-3-19(4-2)14-15-21-17(20)18(12-8-9-13-18)16-10-6-5-7-11-16/h5-7,10-11H,3-4,8-9,12-15H2,1-2H3
  • Key:OFAIGZWCDGNZGT-UHFFFAOYSA-N

Caramiphen is an anticholinergic drug used in the treatment of Parkinson's disease. [1] In combination with phenylpropanolamine it is used as a cough suppressant and nasal decongestant to treat symptoms associated with respiratory illnesses such as cold, allergies, hay fever, and sinusitis. [2] It was added to the British National Formulary in 1963, with a dosage of 10 to 20 mg. Side effects include nausea, dizziness, and drowsiness. [3]

It binds to the sigma-1 receptor with an IC50 value of 25 nM. [4]

Related Research Articles

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References

  1. "Caramiphen". drugs.com. Retrieved 26 September 2012.
  2. "Caramiphen with phenylpropanolamine-oral, Ordrine AT, Rescaps-D, Tuss Vernade, Tusso-Gest". medicine.net. Archived from the original on 29 October 2012. Retrieved 26 September 2012.
  3. Beirn SF, Lavelle S (May 1964). "To-day's drugs: Cough suppressants". British Medical Journal. 1 (5391): 1165–1167. doi:10.1136/bmj.1.5391.1165. PMC   1813498 . PMID   14120813.
  4. Musacchio JM, Klein M (June 1988). "Dextromethorphan binding sites in the guinea pig brain". Cellular and Molecular Neurobiology. 8 (2): 149–156. doi:10.1007/BF00711241. PMID   3044591. S2CID   33844132.