Bunaftine

Bunaftine
Clinical data
ATC code	C01BD03 ( WHO );
Identifiers
	IUPAC name N-[2-(Diethylamino)ethyl]-N-propylnaphthalene-1-carboxamide;
CAS Number	32421-46-8 ;
PubChem CID	36131 ;
ChemSpider	33233 ;
UNII	GH09PRQ3FU ;
KEGG	D07428 ;
ChEMBL	ChEMBL2104200 ;
CompTox Dashboard (EPA)	DTXSID90186165 ;
ECHA InfoCard	100.046.373
Chemical and physical data
Formula	C21H30N2O
Molar mass	326.484 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=C(N(CCCC)CCN(CC)CC)c2cccc1ccccc12;
	InChI InChI=1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3 ; Key:WWGZXRYELYWJBD-UHFFFAOYSA-N ;
	(verify)

Last updated January 03, 2026

Bunaftine (or bunaphtine^[1]) is an antiarrhythmic agent.^[2] It is classified in class III.^[3]

References

↑ Tamargo J (August 1980). "Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers". Arch Int Pharmacodyn Ther. 246 (2): 224–36. PMID 7436628.
↑ Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M (May 1983). "Intropic effects of several antiarrhythmic drugs". Jpn Heart J. 24 (3): 377–90. doi: 10.1536/ihj.24.377 . PMID 6876382.
↑ Fenici R, Marchei M, Bellocci F, Zecchi P (July 1977). "Effect of bunaphtine on right atrial repolarisation in man". Br Heart J. 39 (7): 787–94. doi:10.1136/hrt.39.7.787. PMC 483317 . PMID 328029.

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[pmid7436628-1] Tamargo J (August 1980). "Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers". Arch Int Pharmacodyn Ther. 246 (2): 224–36. PMID 7436628.

[pmid6876382-2] Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M (May 1983). "Intropic effects of several antiarrhythmic drugs". Jpn Heart J. 24 (3): 377–90. doi: 10.1536/ihj.24.377 . PMID 6876382.

[pmid328029-3] Fenici R, Marchei M, Bellocci F, Zecchi P (July 1977). "Effect of bunaphtine on right atrial repolarisation in man". Br Heart J. 39 (7): 787–94. doi:10.1136/hrt.39.7.787. PMC 483317 . PMID 328029.

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[2]

[3]

Clinical data

ATC code	C01BD03 ( WHO )
Identifiers
IUPAC name N-[2-(Diethylamino)ethyl]-N-propylnaphthalene-1-carboxamide
CAS Number	32421-46-8 ^Y
PubChem CID	36131
ChemSpider	33233 ^Y
UNII	GH09PRQ3FU
KEGG	D07428 ^Y
ChEMBL	ChEMBL2104200
CompTox Dashboard (EPA)	DTXSID90186165
ECHA InfoCard	100.046.373
Chemical and physical data
Formula	C₂₁H₃₀N₂O
Molar mass	326.484 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(N(CCCC)CCN(CC)CC)c2cccc1ccccc12
InChI InChI=1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3^Y Key:WWGZXRYELYWJBD-UHFFFAOYSA-N^Y
(verify)