Phenacemide

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Phenacemide
Phenacemide.svg
Clinical data
Trade names Phenurone
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ATC code
Pharmacokinetic data
Elimination half-life 22–25 hours
Identifiers
  • N-Carbamoyl-2-phenyl-acetamide
CAS Number
PubChem CID
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ChemSpider
UNII
KEGG
ChEMBL
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Chemical and physical data
Formula C9H10N2O2
Molar mass 178.191 g·mol−1
3D model (JSmol)
  • O=C(NC(=O)N)Cc1ccccc1
  • InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13) Yes check.svgY
  • Key:XPFRXWCVYUEORT-UHFFFAOYSA-N Yes check.svgY
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Phenacemide (INN, BAN) (brand name Phenurone), also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class. [1] It is a congener and ring-opened analogue of phenytoin (a hydantoin), [2] [3] and is structurally related to the barbiturates and to other hydantoins. [4] Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn due to toxicity. [2] [3]

Contents

See also

References

  1. ↑ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1578–. ISBN   978-0-412-46630-4.
  2. 1 2 Prasad JP (2010). "Central Nervous System". Conceptual Pharmacology. Universities Press. pp. 236–. ISBN   978-81-7371-679-9.
  3. 1 2 Saxena AK, Saxena M (1995). "Developments in anticonvulsants". In deStevens G, Zingel V, Leschke C, Hoeprich P, Schultz R, Mehrotra P, et al. (eds.). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Vol. 44. Basel: Birkhäuser. pp. 185–291. doi:10.1007/978-3-0348-7161-7_6. ISBN   978-3-0348-7161-7. PMID   7644666.{{cite book}}: |journal= ignored (help)
  4. ↑ Kadam SS, Mahadik KR, Bothara KG (1 July 2007). "Central Nervous System Depresants". Principles of Medicinal Chemistry. Vol. II. Pragati Books Pvt. Ltd. pp. 147–. ISBN   978-81-85790-03-9.

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