Arylalkylamine

Substituted arylalkylamines, also alternatively known in many cases as substituted arylethylamines, ^[1] are a group of chemical compounds. ^{[2] [3] [4] [5]} These compounds are divided into two main categories: indolylalkylamines and phenylalkylamines. ^{[2] [5]}

• Indolylalkylamines include substances like tryptamines, which are found in some natural compounds and can affect mood and perception. ^[2]
• Phenylalkylamines include substances like phenethylamines and amphetamines, which are found in both natural and synthetic forms. ^{[2] [5]}

These compounds are related to monoamine neurotransmitters, which are chemicals in the brain that transmit signals between nerve cells. Because of this, substituted arylalkylamines can have a wide range of effects on the body and mind. They are used in many medications, including:

• Psychostimulants, which increase alertness and energy.
• Anorectics, which suppress appetite.
• Wakefulness-promoting agents, which help people stay awake.
• Bronchodilators, which make breathing easier.
• Decongestants, which relieve nasal congestion.
• Antidepressants, which are used to treat depression.
• Entactogens, which enhance feelings of emotional closeness.
• Psychedelics, which alter perception and consciousness.

Many arylalkylamines act as monoamine releasing agents, monoamine reuptake inhibitors, and/or monoamine receptor modulators.

Examples of arylalkylamines and related compounds of different classes

• 
  Phenethylamine
• 
  Thiopropamine
• 
  2-Furylethylamine
• 
  2-Tetrahydrofurylethylamine
• 
  2-Pyrrolylethylamine
• 
  3-Pyrrolylethylamine
• 
  Cyclopentamine
• 
  Propylhexedrine
• 
  Tryptamine
• 
  Isotryptamine
• 
  1ZP2MA
• 
  3-APB
• 
  3-APBT
• 
  Methylhexanamine
• 
  Histamine
• 
  Muscimol

Many more foundational arylalkylamines besides the above also exist. ^[5] In addition, other alkylamines and non-aromatic cyclized alkylamines exist. ^[6]

See also

• Amine
• Alkylamine
• Arylamine

References

1. Freeman S, Alder JF (July 2002). "Arylethylamine psychotropic recreational drugs: a chemical perspective". Eur J Med Chem. 37 (7): 527–539. doi:10.1016/s0223-5234(02)01382-x. PMID   12126772.
2. Glennon RA (October 1999). "Arylalkylamine drugs of abuse: an overview of drug discrimination studies". Pharmacol. Biochem. Behav. 64 (2): 251–256. doi:10.1016/S0091-3057(99)00045-3. PMID   10515299. S2CID   10221368.
3. Richard K. Ries; Shannon C. Miller; David A. Fiellin (2009). Principles of Addiction Medicine. Lippincott Williams & Wilkins. pp. 245–. ISBN   978-0-7817-7477-2.
4. Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 639–. ISBN   978-1-60913-345-0.
5. Trachsel D, Lehmann D, Enzensperger C (2013). "[Kapitel 4:] Heteroarylalkylamine" [[Chapter 4:] Heteroarylalkylamines]. Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German). Solothurn: Nachtschatten-Verlag. pp. 289–346. ISBN   978-3-03788-700-4. OCLC   858805226 . Retrieved 29 January 2025.
6. Trachsel D, Lehmann D, Enzensperger C (2013). "[Kapitel 5:] Ersatz des Arylteils durch nichtaromatische Reste" [[Chapter 5:] Replacement of the Aryl Moiety by Non-Aromatic Residues]. Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German). Solothurn: Nachtschatten-Verlag. pp. 289–346. ISBN   978-3-03788-700-4. OCLC   858805226 . Retrieved 29 January 2025.