Aminoindane

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Aminoindane refers to a class of compounds that are structurally related to indane, a bicyclic hydrocarbon. These compounds are characterized by the presence of an amino group attached to the indane structure. Aminoindanes have been studied for their potential applications in various fields, including medicine and neuroscience.

Contents

Chemical structure and properties

Aminoindanes are typically divided into two main isomers: 1-Aminoindane and 2-Aminoindane. Each isomer has unique properties and potential applications.

1-Aminoindane

1-Aminoindane (1-AI) is known for its pharmacological activity, particularly as a neuroprotective agent. It is a metabolite of the antiparkinsonian drug rasagiline and has been studied for its potential to modulate catecholamine levels in the brain. [1]

2-Aminoindane

2-Aminoindane (2-AI) is a research chemical with applications in neurological disorders and psychotherapy. It acts as a selective substrate for norepinephrine and dopamine transporters. [2] 2-AI has also been sold as a designer drug and is known to have stimulant effects similar to those of amphetamines. [3]

Derivatives and analogues

Several derivatives and analogues of aminoindanes have been developed, each with distinct pharmacological profiles. Notable derivatives include:

The legal status of aminoindanes varies by country. For example, 2-AI is a controlled substance in China and Sweden. [5] In the United States, it is not scheduled at the federal level but may be considered an analogue of amphetamine, making its sale or possession potentially prosecutable under the Federal Analogue Act. [6]

Applications and research

Aminoindanes have been explored for their potential therapeutic uses, particularly in the treatment of neurological disorders. They have also been studied for their stimulant and empathogenic effects, which have led to their use as designer drugs. [7]

Safety and toxicity

While aminoindanes have shown promise in various applications, their safety and toxicity profiles are still under investigation. Some studies have reported toxic effects in both animal models and clinical settings. [8]

Related Research Articles

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<span class="mw-page-title-main">5-IAI</span> Chemical compound

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<span class="mw-page-title-main">2-Aminoindane</span> Chemical compound

2-Aminoindane (2-AI) is an aminoindane and research chemical with applications in neurologic disorders and psychotherapy that has also been sold as a designer drug. It acts as a selective substrate for NET and DAT.

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(<i>R</i>)-1-Aminoindane Major metabolite of rasagiline

(R)-1-Aminoindane ((R)-1-AI; developmental code name TVP-136 or TV-136), or (R)-1-aminoindan, is the major metabolite of the selective MAO-B inhibitor and antiparkinsonian agent rasagiline ((R)-N-propargyl-1-aminoindane). In contrast to rasagiline, it lacks significant monoamine oxidase inhibition. In addition, unlike selegiline and its amphetamine metabolites, it lacks monoamine reuptake-inhibiting and -releasing activities and associated amphetamine-like psychostimulant effects. However, (R)-1-aminoindane retains neuroprotective effects and certain other activities.

<span class="mw-page-title-main">Phenatine</span> Amphetamine psychostimulant

Phenatine, or phenatin, also known as N-nicotinoylamphetamine and sold under the brand name Fenatine, is a psychostimulant of the amphetamine family which was developed and used in the Soviet Union. It was used in the treatment of depression, narcolepsy, post-encephalitis sequelae, alcoholic psychoses, asthenia, and other conditions.

References

  1. ↑ Details on 1-Aminoindane and its pharmacological activity.
  2. ↑ Information about 2-Aminoindane and its derivatives.
  3. ↑ Information about 2-Aminoindane and its derivatives.
  4. ↑ Information about 2-Aminoindane and its derivatives
  5. ↑ Information about 2-Aminoindane and its derivatives.
  6. ↑ Information about 2-Aminoindane and its derivatives.
  7. ↑ Information about 2-Aminoindane and its derivatives.
  8. ↑ Information about 2-Aminoindane and its derivatives.
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