Terodiline

Last updated
Terodiline
Terodiline.png
Clinical data
ATC code
Identifiers
  • N-tert-butyl-4,4-di(phenyl)butan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C20H27N
Molar mass 281.443 g·mol−1
3D model (JSmol)
  • c1ccccc1C(c2ccccc2)CC(NC(C)(C)C)C
  • InChI=1S/C20H27N/c1-16(21-20(2,3)4)15-19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5-14,16,19,21H,15H2,1-4H3 Yes check.svgY
  • Key:UISARWKNNNHPGI-UHFFFAOYSA-N Yes check.svgY
   (verify)

Terodiline is a drug used in urology as an antispasmodic.

It relaxes the smooth muscle and used to reduce bladder tone in treatment of urinary frequency and incontinence. Muscle relaxation caused by terodiline, is probably due to its anticholinergic and calcium antagonist activity.

However, it also blocks Kv11.1 ion channels and consequently can pose a risk for torsades de pointes. This cardiotoxicity is concentration dependent. [1]

References

  1. ↑ Thomas SH, Higham PD, Hartigan-Go K, Kamali F, Wood P, Campbell RW, Ford GA (1995). "Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence". Br Heart J. 74 (1): 53–6. doi:10.1136/hrt.74.1.53. PMC   483946 . PMID   7662454.


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