Encainide

Last updated
Encainide
Encainide.svg
Clinical data
Trade names Enkaid
AHFS/Drugs.com Micromedex Detailed Consumer Information
MedlinePlus a605040
ATC code
Legal status
Legal status
  • Withdrawn
Identifiers
  • 4-Methoxy-N-[2-(1-methyl-2-piperidin-1-ylethyl)phenyl]benzamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C22H28N2O2
Molar mass 352.478 g·mol−1
3D model (JSmol)
  • COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1
  • InChI=1S/C22H28N2O2/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25) Yes check.svgY
  • Key:PJWPNDMDCLXCOM-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects. [1]

Contents

Synthesis

Synthesis: < Encainide synthesis.svg
Synthesis: <

See also

References

  1. ↑ Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH, et al. (March 1991). "Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial". The New England Journal of Medicine. 324 (12): 781–8. doi: 10.1056/NEJM199103213241201 . PMID   1900101.
  2. ↑ Dykstra SJ, Minielli JL, Lawson JE, Ferguson HC, Dungan KW (September 1973). "Lysergic acid and quinidine analogs. 2-(o-Acylaminophenethyl)piperidines". Journal of Medicinal Chemistry. 16 (9): 1015–20. doi:10.1021/jm00267a012. PMID   4745503.
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