Fendiline

Fendiline

Clinical data
ATC code	C08EA01 ( WHO )
Identifiers
IUPAC name 3,3-diphenyl-N-(1-phenylethyl)propan-1-amine
CAS Number	13042-18-7  Y
PubChem CID	3336
DrugBank	DB08980  N
ChemSpider	3219  N
UNII	S253D559A8
KEGG	D07185  Y
ChEMBL	ChEMBL254832  N
CompTox Dashboard (EPA)	DTXSID5048473
ECHA InfoCard	100.032.635
Chemical and physical data
Formula	C23H25N
Molar mass	315.460 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3
InChI InChI=1S/C23H25N/c1-19(20-11-5-2-6-12-20)24-18-17-23(21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16,19,23-24H,17-18H2,1H3 N Key:NMKSAYKQLCHXDK-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

Fendiline is a nonselective calcium channel blocker. ^[1]

References

1. Scultéty S, Tamáskovits E (1991). "Effect of Ca2+ antagonists on isolated rabbit detrusor muscle". Acta Physiologica Hungarica. 77 (3–4): 269–78. PMID   1755331.

Further reading

• Bayer, R; Mannhold, R (1987). "Fendiline: a review of its basic pharmacological and clinical properties". Pharmatherapeutica. 5 (2): 103–136. OCLC   115670794. PMID   3310016.
• van der Hoeven, Dharini; Cho, Kwang-jin; Ma, Xiaoping; Chigurupati, Sravanthi; Parton, Robert G.; Hancock, John F. (2013). "Fendiline Inhibits K-Ras Plasma Membrane Localization and Blocks K-Ras Signal Transmission". Molecular and Cellular Biology. 33 (2): 237–251. doi:10.1128/MCB.00884-12. PMC   3554123 . PMID   23129805.
• Woods, Neha; Trevino, Jose; Coppola, Domenico; Chellappan, Srikumar; Yang, Shengyu; Padmanabhan, Jaya (3 November 2015). "Fendiline inhibits proliferation and invasion of pancreatic cancer cells by interfering with ADAM10 activation and β-catenin signaling". Oncotarget. 6 (34): 35931–35948. doi:10.18632/oncotarget.5933. PMID   26440150.
• Kukovetz, W. R.; Brunner, F.; Beubler, E.; Weyhenmeyer, R.; Lohaus, R.; Grob, M.; Mayer, D. (April 1982). "Single dose pharmacokinetics of fendiline in humans". European Journal of Drug Metabolism and Pharmacokinetics. 7 (2): 105–110. doi:10.1007/BF03188726. PMID   7117293.
• Huang, Cc; Huang, Cj; Cheng, Js; Liu, Si; Chen, Is; Tsai, Jy; Chou, Ct; Tseng, Pl; Jan, Cr (January 2009). "Fendiline-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in human oral cancer cells". Human & Experimental Toxicology. 28 (1): 41–48. Bibcode:2009HETox..28...41H. doi:10.1177/0960327108097436. PMID   19411560.
• Lin, Muh-Chiou; Jan, Chung-Ren (July 2002). "The anti-anginal drug fendiline elevates cytosolic Ca2+ in rabbit corneal epithelial cells". Life Sciences. 71 (9): 1071–1079. doi:10.1016/S0024-3205(02)01797-6. PMID   12088766.
• Jan, C. R.; Lee, K. C.; Chou, K. J.; Cheng, J. S.; Wang, J. L.; Lo, Y. K.; Chang, H. T.; Tang, K. Y.; Yu, C. C.; Huang, J. K. (July 2001). "Fendiline, an anti-anginal drug, increases intracellular Ca2+ in PC3 human prostate cancer cells". Cancer Chemotherapy and Pharmacology. 48 (1): 37–41. doi:10.1007/s002800000262. PMID   11488522.