Naminidil

Last updated

Naminidil
Naminidil.svg
Clinical data
Other namesBMS-234303; BMS234303
Routes of
administration
Topical [1]
Drug class ATP-sensitive potassium channel opener; Vasodilator
Identifiers
  • 1-cyano-3-(4-cyanophenyl)-2-[(2R)-3,3-dimethylbutan-2-yl]guanidine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C15H19N5
Molar mass 269.352 g·mol−1
3D model (JSmol)
  • C[C@H](C(C)(C)C)N=C(NC#N)NC1=CC=C(C=C1)C#N
  • InChI=1S/C15H19N5/c1-11(15(2,3)4)19-14(18-10-17)20-13-7-5-12(9-16)6-8-13/h5-8,11H,1-4H3,(H2,18,19,20)/t11-/m1/s1
  • Key:PGYDRGZVXVVZQC-LLVKDONJSA-N

Naminidil (INN Tooltip International Nonproprietary Name, USAN Tooltip United States Adopted Name; developmental code name BMS-234303) is an ATP-sensitive potassium channel opener with vasodilator activity which was under development as a topical medication for the treatment of androgenic alopecia (pattern hair loss) but was never marketed. [2] [3] [1] The drug was under development by Bristol-Myers Squibb and reached phase 2 clinical trials by 2001. [2] One of the phase 2 trials compared naminidil, minoxidil, and placebo for alopecia. [1] However, no results of the study appear to have been made available. [1] Development of naminidil was discontinued by 2008. [2] In terms of chemical structure, naminidil is a guanidine derivative and is structurally distinct from minoxidil. [2] [4]

See also

References

  1. 1 2 3 4 Poulos GA, Mirmirani P (February 2005). "Investigational medications in the treatment of alopecia". Expert Opinion on Investigational Drugs. 14 (2): 177–184. doi:10.1517/13543784.14.2.177. PMID   15757393.
  2. 1 2 3 4 "Naminidil". AdisInsight. 17 January 2008. Retrieved 23 July 2025.
  3. "Delving into the Latest Updates on Naminidil with Synapse". Synapse. 20 July 2025. Retrieved 23 July 2025.
  4. "Naminidil". PubChem. U.S. National Library of Medicine. Retrieved 24 July 2025.