Tolfenamic acid

Last updated
Tolfenamic acid
Tolfenamic acid FormulaV1.svg
Clinical data
Trade names Clotam, Clotan, Tufnil
AHFS/ International Drug Names
Routes of
By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • 2-[(3-chloro-2-methylphenyl)amino]benzoic acid) [1]
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard 100.033.862 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C14H12ClNO2
Molar mass 261.71 g·mol−1
3D model (JSmol)
  • Clc2cccc(Nc1ccccc1C(=O)O)c2C
  • InChI=1S/C14H12ClNO2/c1-9-11(15)6-4-8-12(9)16-13-7-3-2-5-10(13)14(17)18/h2-8,16H,1H3,(H,17,18) Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Tolfenamic acid (Clotam, Tufnil) is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs discovered by scientists at Medica Pharmaceutical Company in Finland. [2] Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins. [3]

It is used in the UK as a treatment for migraine. [4] It is generally not available in the US. [3] It is available in some Asian, Latin American and European countries as a generic drug for humans and for animals. [5]

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  1. Andersen KV, Larsen S, Alhede B, Gelting N, Buchardt O (1989). "Characterization of two polymorphic forms of tolfenamic acid, N-(2-methyl-3-chlorophenyl)anthranilic acid: their crystal structures and relative stabilities". J. Chem. Soc., Perkin Trans. 2 (10): 1443–1447. doi:10.1039/P29890001443.
  2. Pentikäinen PJ, Neuvonen PJ, Backman C (1981). "Human pharmacokinetics of tolfenamic acid, a new anti-inflammatory agent". European Journal of Clinical Pharmacology. 19 (5): 359–65. doi:10.1007/bf00544587. PMID   7238564. S2CID   9428076.
  3. 1 2 NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
  4. NHS Tolfenamic Acid (Tolfenamic acid 200mg tablets) Page accessed July 3, 2015
  5. international listings for tolfenamic acid Page accessed July 3, 2015