CGS-9896

CGS-9896

Clinical data
ATC code	none
Identifiers
IUPAC name 2-(4-chlorophenyl)-1H-pyrazolo[4,5-c]quinolin-3-one
CAS Number	77779-36-3  Y
PubChem CID	108030
ChemSpider	97139  N
UNII	86PWQ4PVN0
ChEMBL	ChEMBL507327
CompTox Dashboard (EPA)	DTXSID20998970
Chemical and physical data
Formula	C16H10ClN3O
Molar mass	295.73 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C2C(=C1)C3=C(C=N2)C(=O)N(N3)C4=CC=C(C=C4)Cl
InChI InChI=1S/C16H10ClN3O/c17-10-5-7-11(8-6-10)20-16(21)13-9-18-14-4-2-1-3-12(14)15(13)19-20/h1-9,19H N Key:QCBUAKLOWCOUCR-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects to benzodiazepine drugs but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. ^[1]

CGS-9896 is a benzodiazepine receptor partial agonist which produces long-lasting anxiolytic and anticonvulsant effects in animal studies but does not produce sedative effects. ^{[2] [3]} It also increases appetite, ^[4] and reduces the development of gastrointestinal ulcers following chronic stress. ^[5]

References

1. Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of CGS 9896: interactions within the GABA/benzodiazepine receptor complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-3057(88)90342-5. PMID   2854261. S2CID   21773709.
2. Bernasconi R, Marescaux C, Vergnes M, et al. (1988). "Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models". J Neural Transm. 71 (1): 11–27. doi:10.1007/BF01259406. PMID   3343593. S2CID   31525533.
3. Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute experimental intoxication with fluostigmine". Arch. Toxicol. 64 (5): 412–3. Bibcode:1990ArTox..64..412R. doi:10.1007/BF01973465. PMID   2206111. S2CID   19084019.
4. Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem Behav. 51 (2–3): 499–503. doi:10.1016/0091-3057(95)00020-W. PMID   7667375. S2CID   32809713.
5. Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer in rat". Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-1681.1990.tb01298.x. PMID   2109664. S2CID   37492286.