Arfendazam

Arfendazam

Clinical data
ATC code	none
Identifiers
IUPAC name Ethyl 7-chloro-4-oxo-5-phenyl-2,3-dihydro-1,5-benzodiazepine-1-carboxylate
CAS Number	37669-57-1  Y
PubChem CID	65803
ChemSpider	59219  Y
UNII	P37G7BTX8V
ChEMBL	ChEMBL2104444  N
CompTox Dashboard (EPA)	DTXSID20191085
ECHA InfoCard	100.048.694
Chemical and physical data
Formula	C18H17ClN2O3
Molar mass	344.80 g·mol−1
3D model (JSmol)	Interactive image
SMILES ClC1=CC2=C(C=C1)N(CCC(N2C3=CC=CC=C3)=O)C(OCC)=O
InChI InChI=1S/C18H17ClN2O3/c1-2-24-18(23)20-11-10-17(22)21(14-6-4-3-5-7-14)16-12-13(19)8-9-15(16)20/h3-9,12H,2,10-11H2,1H3 Y Key:NXJWVCHVPUCWJS-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Arfendazam (INN) ^[1] is a drug which is a benzodiazepine derivative. Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.

Arfendazam has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives, but is a partial agonist at GABA_A receptors, so the sedative effects are relatively mild and it produces muscle relaxant effects only at very high doses. ^{[2] [3]}

Arfendazam produces an active metabolite lofendazam, which is thought to be responsible for part of its effects. ^[4]

See also

• Benzodiazepine

References

1. "International Nonproprietary Names for Pharmaceutical Substances. Proposed International Nonproprietary Names (Prop. INN): List 39. Supplement to WHO Chronicle" (PDF). World Health Organization. March 1978. p. 3. Retrieved 4 December 2015.
2. Mueller E (January 1985). "Benzodiazepine receptor interactions of arfendazam, a novel 1, 5-benzodiazepine". Pharmacopsychiatry. 18 (1): 10–1. doi:10.1055/s-2007-1017288. S2CID   144951247.
3. Müller WE, Groh B, Bub O (July 1986). "In vitro and in vivo studies of the mechanism of action of arfendazam, a novel 1, 5-benzodiazepine". Pharmacopsychiatry. 19 (4): 314–315. doi:10.1055/s-2007-1017251. S2CID   143919337.
4. Adrien J, Albani F, Baruzzi A, Berger M, Bixler EO, Borbeley AA, Dikeos DG, Drucker-Colin R, Montero RF, Hishikawa Y, Inoue S (December 2012). The Pharmacology of Sleep. Springer Science & Business Media. ISBN   978-3-540-58961-7.