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Clinical data | |
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Other names | MK-6096; MK6096 |
Routes of administration | By mouth |
Drug class | Orexin antagonist |
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Pharmacokinetic data | |
Elimination half-life | 3–6 hours [1] |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.203.042 |
Chemical and physical data | |
Formula | C24H25FN4O2 |
Molar mass | 420.488 g·mol−1 |
3D model (JSmol) | |
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Filorexant (INN , USAN ; developmental code name MK-6096) is an orexin antagonist which was under development by Merck for the treatment of insomnia, depression, diabetic neuropathy, and migraine. [2] [3] It is a dual antagonist of the orexin OX1 and OX2 receptors. [4] [5] It has a relatively short elimination half-life of 3 to 6 hours. [1] However, it dissociates slowly from the orexin receptors and may thereby have a longer duration. [6] Possibly in relation to this, filorexant shows next-day somnolence similarly to suvorexant. [6] In phase 2 clinical trials, filorexant was found to be effective in the treatment of insomnia, [7] but was not effective in the treatment of major depressive disorder, [8] [9] [10] painful diabetic neuropathy, [11] [12] or migraine. [13] As of May 2015 [update] , filorexant was no longer listed on Merck's online development pipeline and hence development of the drug appears to have been discontinued. [14] [1] [2] Development of filorexant may have been discontinued due to lack of differentiation from suvorexant (which was also developed by Merck). [6]