EMPA (drug)

EMPA

Clinical data
ATC code	none
Identifiers
IUPAC name N-Ethyl-N2-(6-methoxy-3-pyridinyl)-N2-[(2-methylphenyl)sulfonyl]-N-(3-pyridinylmethyl)glycinamide
CAS Number	680590-49-2  Y
PubChem CID	9981404
ChemSpider	8156996
UNII	VT87V86D7W
CompTox Dashboard (EPA)	DTXSID101045254
ECHA InfoCard	100.233.393
Chemical and physical data
Formula	C23H26N4O4S
Molar mass	454.55 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC1=CN=CC=C1)C(=O)CN(C2=CN=C(C=C2)OC)S(=O)(=O)C3=CC=CC=C3C
InChI InChI=1S/C23H26N4O4S/c1-4-26(16-19-9-7-13-24-14-19)23(28)17-27(20-11-12-22(31-3)25-15-20)32(29,30)21-10-6-5-8-18(21)2/h5-15H,4,16-17H2,1-3H3 Key:KJPHTXTWFHVJIG-UHFFFAOYSA-N

EMPA is a selective antagonist of the OX₂ receptor, with 900-fold selectivity in binding for OX₂ over OX₁. ^{[1] [2]}

See also

• TCS-OX2-29

References

1. Malherbe P, Borroni E, Pinard E, Wettstein JG, Knoflach F (September 2009). "Biochemical and electrophysiological characterization of almorexant, a dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist: comparison with selective OX1 and OX2 antagonists". Molecular Pharmacology. 76 (3): 618–31. doi:10.1124/mol.109.055152. PMID   19542319. S2CID   5702143.
2. Malherbe P, Borroni E, Gobbi L, Knust H, Nettekoven M, Pinard E, et al. (April 2009). "Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor". British Journal of Pharmacology. 156 (8): 1326–41. doi:10.1111/j.1476-5381.2009.00127.x. PMC   2697736 . PMID   19751316.