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Clinical data | |
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Other names | ACT-539313; ACT539313 |
Routes of administration | Oral |
Drug class | Orexin receptor antagonist |
Pharmacokinetic data | |
Elimination half-life | 3.3–6.5 hours [1] [2] |
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Chemical and physical data | |
Formula | C23H23N7O2 |
Molar mass | 429.484 g·mol−1 |
3D model (JSmol) | |
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Nivasorexant (INN ; developmental code name ACT-539313) is an orexin antagonist medication which is under development for the treatment of binge eating disorder and was previously under development for the treatment of anxiety disorders. [4] [5] [6] [7] [1] [2]
It is an orally active small-molecule compound with an elimination half-life of 3.3 to 6.5 hours and acts as a selective orexin OX1 receptor antagonist (1-SORA). [4] [1] [2]
As of May 2022, the drug is in phase 2 clinical trials for binge eating disorder. [4] Following negative efficacy results of a phase 2 trial of nivasorexant for binge eating disorder, Idorsia (the developer of nivasorexant) signaled in May 2022 that it would not pursue further development of the drug for this indication. [8]
ACT-539313 ((4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)- 3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone) is an orally active, reversible, selective OX1 receptor antagonist (1-SORA) that readily crosses the blood–brain barrier.