Flubromazepam

Last updated

Flubromazepam
Flubromazepam.svg
Clinical data
Routes of
administration 		Oral
Legal status
Legal status
Pharmacokinetic data
Elimination half-life 106 hours
Identifiers
  • 7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.428.842 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C15H10BrFN2O
Molar mass 333.160 g·mol−1
3D model (JSmol)
  • BrC1=CC(C(C2=CC=CC=C2F)=NC3)=C(C=C1)NC3=O
  • InChI=1S/C15H10BrFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
  • Key:ZRKDDZBVSZLOFS-UHFFFAOYSA-N

Flubromazepam is a benzodiazepine derivative which was first synthesized in 1960, [1] but was never marketed and did not receive any further attention or study until late 2012 when it appeared on the grey market as a novel designer drug. [2] [3] [4] [5] [6] [7] [8]

Contents

It is a structural analog of phenazepam in which the chlorine atom has been replaced by a fluorine atom.

An alternate isomer, 5-(2-bromophenyl)-7-fluoro-1,3-dihydro-2H-1,4-benzodiazepin-2-one or "iso-flubromazepam", [9] may have been sold under the same name. [2]

Alternate isomer Flubromazepam isomer.svg
Alternate isomer

United Kingdom

In the UK, flubromazepam has been classified as a Class C drug by the May 2017 amendment to The Misuse of Drugs Act 1971 along with several other designer benzodiazepine drugs. [10]

United States

Flubromazepam, clonazolam, and flubromazolam are Schedule I controlled substances under Virginia State Law. [11]

See also

References

  1. ↑ US 3136815,"Amino substituted benzophenone oximes and derivatives thereof"
  2. 1 2 Moosmann B, Huppertz LM, Hutter M, Buchwald A, Ferlaino S, Auwärter V (November 2013). "Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics". Journal of Mass Spectrometry. 48 (11): 1150–9. Bibcode:2013JMSp...48.1150M. doi:10.1002/jms.3279. PMID   24259203.
  3. ↑ Moosmann B, Hutter M, Huppertz LM, Auwärter V. "Characterization of the designer benzodiazepines pyrazolam and flubromazepam and study on their detectability in human serum and urine samples" (PDF). Institute of Forensic Medicine, Forensic Toxicology, University Medical Center Freiburg, Freiburg, Germany.
  4. ↑ O'Connor LC, Torrance HJ, McKeown DA (March 2016). "ELISA Detection of Phenazepam, Etizolam, Pyrazolam, Flubromazepam, Diclazepam and Delorazepam in Blood Using Immunalysis® Benzodiazepine Kit". Journal of Analytical Toxicology. 40 (2): 159–61. doi: 10.1093/jat/bkv122 . PMID   26518230.
  5. ↑ "Flubromazepam". New Synthetic Drugs Database. 12 November 2023. Archived from the original on 16 March 2022. Retrieved 2 February 2016.
  6. ↑ Pettersson Bergstrand M, Helander A, Hansson T, Beck O (April 2017). "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Testing and Analysis. 9 (4): 640–645. doi:10.1002/dta.2003. PMID   27366870.
  7. ↑ Høiseth G, Tuv SS, Karinen R (November 2016). "Blood concentrations of new designer benzodiazepines in forensic cases". Forensic Science International. 268: 35–38. doi:10.1016/j.forsciint.2016.09.006. PMID   27685473.
  8. ↑ Manchester KR, Maskell PD, Waters L (March 2018). "a and plasma protein binding values for benzodiazepines appearing as new psychoactive substances" (PDF). Drug Testing and Analysis. doi:10.1002/dta.2387. PMID   29582576. S2CID   31098917.
  9. ↑ Baumeister D, Tojo LM, Tracy DK (April 2015). "Legal highs: staying on top of the flood of novel psychoactive substances". Therapeutic Advances in Psychopharmacology. 5 (2): 97–132. doi:10.1177/2045125314559539. PMC   4521440 . PMID   26240749.
  10. ↑ "The Misuse of Drugs Act 1971 (Amendment) Order 2017". Legislation.gov.uk.
  11. ↑ "Administrative Code 18VAC110-20-322. Placement of Chemicals in Schedule I." Virginia Law.
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