Girisopam

Girisopam

Clinical data
ATC code	none
Identifiers
IUPAC name 1-(3-chlorophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine
CAS Number	82230-53-3  Y
PubChem CID	71257
ChemSpider	64387  Y
UNII	2LP301A921
ChEMBL	ChEMBL1915065  N
CompTox Dashboard (EPA)	DTXSID70231642
Chemical and physical data
Formula	C18H17ClN2O2
Molar mass	328.80 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc3cccc(C\2=N\N=C(/Cc1c/2cc(OC)c(OC)c1)C)c3
InChI InChI=1S/C18H17ClN2O2/c1-11-7-13-9-16(22-2)17(23-3)10-15(13)18(21-20-11)12-5-4-6-14(19)8-12/h4-6,8-10H,7H2,1-3H3 Y Key:VQYLGVVODFDFNK-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Girisopam ^[1] (GYKI-51189, EGIS-5810) is a drug which is a 2,3-benzodiazepine derivative, related to tofisopam ^[2] and zometapine. It has selective anxiolytic action with no sedative, anticonvulsant or muscle relaxant effects. ^{[2] [3] [4]}

See also

• Benzodiazepine

References

1. US 4322346,Korosi J, Lang T, Szekely J, Andrasi F, Zolyomi G, Borsi J, Katali G, Hamori T, Gabriella S, Zsuz MN, Miglecz E,"5H-2,3-Benzodiazepine derivatives",issued 30 March 1982 
2. Andrási F, Horváth K, Sineger E, Berzsenyi P, Borsy J, Kenessey A, Tarr M, Láng T, Kórösi J, Hámori T (October 1987). "Neuropharmacology of a new psychotropic 2,3-benzodiazepine". Arzneimittel-Forschung. 37 (10): 1119–24. PMID   2893623.
3. Horváth K, Andrási F, Botka P, Hámori T (1992). "Anxiolytic profile of girisopam and GYKI 52,322 (EGIS 6775). Comparison with chlordiazepoxide and buspirone". Acta Physiologica Hungarica. 79 (2): 153–61. PMID   1363928.
4. Horváth EJ, Salamon C, Bakonyi A, Fekete MI, Palkovits M (July 1999). "[(3)H]-girisopam, a novel selective benzodiazepine for the 2, 3-benzodiazepine binding site". Brain Research. Brain Research Protocols. 4 (2): 230–5. doi:10.1016/s1385-299x(99)00025-2. PMID   10446419.