Clazolam

Last updated
Clazolam
Clazolam.svg
Clinical data
ATC code
  • None
Identifiers
  • 2-chloro-5-methyl-5,9,10,14b-tetrahydroisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C18H17ClN2O
Molar mass 312.80 g·mol−1
3D model (JSmol)
  • Clc2ccc1N(C(=O)CN4C(c1c2)c3c(cccc3)CC4)C

Clazolam [1] (SAH-1123), also referred to as isoquinazepon, is a drug which is a fused benzodiazepine and tetrahydroisoquinoline derivative. [2] It was developed in the 1960s but was never marketed. [2] It possesses anxiolytic effects and is also claimed to have antidepressant properties. [2] [3]

See also

Related Research Articles

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<span class="mw-page-title-main">Diazepam</span> Benzodiazepine sedative

Diazepam, first marketed as Valium, is a medicine of the benzodiazepine family that acts as an anxiolytic. It is commonly used to treat a range of conditions, including anxiety, seizures, alcohol withdrawal syndrome, muscle spasms, insomnia, and restless legs syndrome. It may also be used to cause memory loss during certain medical procedures. It can be taken orally, as a suppository inserted into the rectum, intramuscularly, intravenously or used as a nasal spray. When injected intravenously, effects begin in one to five minutes and last up to an hour. Orally, effects begin after 15 to 60 minutes.

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<span class="mw-page-title-main">Zopiclone</span> Hypnotic medication

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<span class="mw-page-title-main">Nitrazepam</span> Benzodiazepine sedative

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<span class="mw-page-title-main">Flurazepam</span> Hypnotic medication

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<span class="mw-page-title-main">Estazolam</span> Tranquilizer

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<span class="mw-page-title-main">Clorazepate</span> Benzodiazepine medication

Clorazepate, sold under the brand name Tranxene among others, is a benzodiazepine medication. It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant properties. Clorazepate is an unusually long-lasting benzodiazepine and serves as a prodrug for the equally long-lasting desmethyldiazepam, which is rapidly produced as an active metabolite. Desmethyldiazepam is responsible for most of the therapeutic effects of clorazepate.

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Medazepam is a drug that is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and skeletal muscle relaxant properties. It is known by the following brand names: Azepamid, Nobrium, Tranquirax, Rudotel, Raporan, Ansilan and Mezapam. Medazepam is a long-acting benzodiazepine drug. The half-life of medazepam is 36–200 hours.

<span class="mw-page-title-main">Prazepam</span> Chemical compound

Prazepam is a benzodiazepine derivative drug developed by Warner-Lambert in the 1960s. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. Prazepam is a prodrug for desmethyldiazepam which is responsible for the therapeutic effects of prazepam.

<span class="mw-page-title-main">Fludiazepam</span> Chemical compound

Fludiazepam, marketed under the brand name Erispan (エリスパン) is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam, originally developed by Hoffmann-La Roche in the 1960s. It is marketed in Japan and Taiwan. It exerts its pharmacological properties via enhancement of GABAergic inhibition. Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Fludiazepam has been used recreationally.

<span class="mw-page-title-main">Chlordiazepoxide</span> Benzodiazepine class sedative and hypnotic medication

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<span class="mw-page-title-main">DMCM</span> Chemical compound

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<span class="mw-page-title-main">Menitrazepam</span> Chemical compound

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<span class="mw-page-title-main">Tracazolate</span> Chemical compound

Tracazolate (ICI-136,753) is an anxiolytic drug which is used in scientific research. It is a pyrazolopyridine derivative, most closely related to pyrazolopyrimidine drugs such as zaleplon, and is one of a structurally diverse group of drugs known as the nonbenzodiazepines which act at the same receptor targets as benzodiazepines but have distinct chemical structures.

<span class="mw-page-title-main">Viqualine</span> Medication

Viqualine (INN) is an antidepressant and anxiolytic drug that was never marketed. It acts as a potent and selective serotonin releasing agent and serotonin reuptake inhibitor. In addition, viqualine displaces diazepam from the GABAA receptor and produces benzodiazepine-like effects, indicating that it is also a positive allosteric modulator of the benzodiazepine site of the GABAA receptor. The drug has mainly been researched as a potential treatment for alcoholism.

The Bobbitt reaction is a name reaction in organic chemistry. It is named after the American chemist James M. Bobbitt. The reaction allows the synthesis of 1-, 4-, and N-substituted 1,2,3,4-tetrahydroisoquinolines and also 1-, and 4-substituted isoquinolines.

References

  1. NL 6510987
  2. 1 2 3 Triggle DJ (1997). Dictionary of pharmacological agents. London: Chapman & Hall. p. 476. ISBN   0-412-46630-9.
  3. Potikha LM, Kovtunenko VA (2009). "Synthesis and properties of 3-aminodihydroisoquinolines". Russian Chemical Reviews. 78 (6): 513–533. Bibcode:2009RuCRv..78..513P. doi:10.1070/RC2009v078n06ABEH004041. S2CID   250824624.[ permanent dead link ]