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| Clinical data | |
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| Other names | Enallylpropymal |
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| UNII | |
| ECHA InfoCard | 100.015.876 |
| Chemical and physical data | |
| Formula | C11H16N2O3 |
| Molar mass | 224.260 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Enallylpropymal (Narconumal) is a barbiturate derivative developed by Hoffman la Roche in the 1930s. [1] It has sedative and hypnotic effects and is considered to have a moderate abuse potential. [2]
Stephen Roche is an Irish former professional road racing cyclist. In a 13-year professional career, he peaked in 1987, becoming the second of only two cyclists to win the Triple Crown of victories in the Tour de France and the Giro d'Italia general classification, plus the World road race championship, the first was Eddy Merckx. Roche's rise coincided with that of fellow Irishman Sean Kelly.
La Roche-Maurice is a commune in the Finistère department of Brittany in northwestern France.
La Roche-sur-Yon is a commune in the Vendée department in the Pays de la Loire region in western France. It is the capital of the department. The demonym for its inhabitants is Yonnais.
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX Swiss Exchange. The company headquarters are located in Basel. Roche is the fifth largest pharmaceutical company in the world by revenue, and the leading provider of cancer treatments globally.
David Adam LaRoche is an American former professional baseball first baseman who played 12 seasons in Major League Baseball (MLB). He played for the Atlanta Braves, Pittsburgh Pirates, Boston Red Sox, Arizona Diamondbacks, Washington Nationals and Chicago White Sox. He is the son of pitcher Dave LaRoche and the brother of third baseman Andy LaRoche.
La Roche University is a private university in McCandless, Pennsylvania. It was founded in 1963 by the Sisters of Divine Providence as a Roman Catholic college and now sits on an 80-acre (320,000 m2) campus in McCandless within the Diocese of Pittsburgh.
Sebastian Roché is a French-Scottish actor. He is known for his roles as Kurt Mendel in Odyssey 5, Jerry Jacks in General Hospital, Thomas Jerome Newton in Fringe, Balthazar in Supernatural, Mikael in both The Vampire Diaries and The Originals, and Reichsminister Martin Heusmann in The Man in the High Castle.
Nicolas Roche is an Irish former professional road bicycle racer who last rode for UCI WorldTeam Team DSM. He has twice been national champion and has twice finished in the top ten of the Vuelta a España, and won stages in 2013 and 2015. He started a total of 24 Grand Tours, finishing 22, and he took a total of 65 top 10 finishes in Grand Tour stages, including 43 on the Vuelta. He represented Ireland at the 2008 Summer Olympics in the road race. He has competed for Ireland 7 times at the road world championships.
Tocilizumab, sold under the brand name Actemra among others, is an immunosuppressive drug, used for the treatment of rheumatoid arthritis and systemic juvenile idiopathic arthritis, a severe form of arthritis in children. It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin 6 (IL-6) is a cytokine that plays an important role in immune response and is implicated in the pathogenesis of many diseases, such as autoimmune diseases, multiple myeloma and prostate cancer. Tocilizumab was jointly developed by Osaka University and Chugai, and was licensed in 2003 by Hoffmann-La Roche.
The Roman Catholic Diocese of Viviers is a diocese of the Latin Rite of the Roman Catholic Church in France. Erected in the 4th century, the diocese was restored in the Concordat of 1822, and comprises the department of Ardèche, in the Region of Rhône-Alpes. Currently the diocese is a suffragan of the Archdiocese of Lyon. Its current bishop is Jean-Louis Marie Balsa, appointed in 2015.
The 1987 Giro d'Italia was the 70th edition of the race. It began on 21 May with a 4 km (2.5 mi) prologue in San Remo, and concluded on 13 June with a 32 km (19.9 mi) individual time trial in Saint-Vincent. A total of 180 riders from 20 teams entered the 22-stage, 3,915 km (2,433 mi)-long race, which was won by Irishman Stephen Roche of the Carrera Jeans–Vagabond team. Second and third places were taken by British rider Robert Millar and Dutchman Erik Breukink, respectively. It was the second time in the history of the Giro that the podium was occupied solely by non-Italian riders. Roche's victory in the 1987 Giro was his first step in completing the Triple Crown of Cycling – winning the Giro d'Italia, the Tour de France, and the World Championship road race in one calendar year – becoming the second rider ever to do so.
Carrera was an Italian-based road bicycle racing team active from 1984 to 1996, named after sponsoring Italian jeans manufacturer Carrera. The team was successful in the Giro d'Italia and the Tour de France with three overall wins and several wins in the Points classification and Mountain Classifications.
La Roche-Bernard is a commune in the Morbihan department of Brittany in north-western France. Inhabitants of La Roche-Bernard are called in French Rochois for men and Rochoises for women.
Ouvrage Roche-la-Croix is a work of the Maginot Line's Alpine extension, the Alpine Line, also known as the Little Maginot Line. The ouvrage consists of one entry block, two infantry blocks, one artillery block and two observation blocks in the vicinity of the Col de Larche. An aerial tram was provided for better access. The position is located at the top of a sheer escarpment that dominates Meyronnes and the valley of the Ubayette.
La Roche-Blanche is a commune in the Loire-Atlantique department in western France.
Diclofensine was developed by Hoffmann-La Roche in the 1970s in the search for a new antidepressant. It was found that the (S)-isomer was responsible for activity. Is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and norepinephrine, with affinities (Ki) of 16.8 nM, 15.7 nM, and 51 nM for DAT, NET, and SERT, respectively. It was found to be an effective antidepressant in human trials, with relatively few side effects, but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential.
Ro48-8684 is a water-soluble benzodiazepine derivative developed by Hoffman-LaRoche in the 1990s, which was designed along with Ro48-6791 as an improved replacement for midazolam, but ultimately proved to have little advantages over the parent drug and has not been introduced into clinical practice.
Events from the year 1470 in France
La Roche was a British Thoroughbred racehorse and broodmare. As a two-year-old in 1899 she showed some promise, winning once from six attempts, but appeared to be some way below top class. In the following season, when tried over longer distance, she emerged as one of the best horses of her generation in England, winning the Oaks Stakes, Manchester Cup, Yorkshire Oaks and Newmarket Oaks as well as finishing fourth in the 1000 Guineas and third in the Doncaster Cup. She was retired at the end of the season to become a broodmare and had considerable success as a dam of winners.
La Roche-Jaudy is a commune in the Côtes-d'Armor department of Brittany in northwestern France. It was established on 1 January 2019 by merger of the former communes of La Roche-Derrien, Hengoat, Pommerit-Jaudy and Pouldouran.
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