Capuride

Capuride
Clinical data
Other names	Pacinox, valnoctylurea
Identifiers
	IUPAC name N-carbamoyl-2-ethyl-3-methylpentanamide;
CAS Number	5579-13-5 ;
PubChem CID	231285 ;
ChemSpider	201505 ;
UNII	3FO9QT93IS ;
KEGG	D03377 ;
ChEBI	CHEBI:134831 ;
ChEMBL	ChEMBL392861 ;
CompTox Dashboard (EPA)	DTXSID5022728 ;
Chemical and physical data
Formula	C9H18N2O2
Molar mass	186.255 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CCC(C)C(CC)C(=O)NC(=O)N;
	InChI InChI=InChI=1S/C9H18N2O2/c1-4-6(3)7(5-2)8(12)11-9(10)13/h6-7H,4-5H2,1-3H3,(H3,10,11,12,13); Key:HLSLSXBFTXUKCY-UHFFFAOYSA-N;

Last updated September 03, 2025

Capuride is a synthetic sedative-hypnotic drug of the N-acylurea class, primarily developed and studied as a preanesthetic agent to promote sleep prior to surgery.^[1] It has a mechanism and duration of action considered similar to that of short-acting barbiturates, although it is chemically distinct. Clinical studies from the 1970s demonstrated capuride's efficacy in facilitating presurgical sleep, situating it among early modern hypnotic agents, but its clinical use has been superseded by safer alternatives.^[2]

References

↑ Katz J, Finestone SC, Pappas MT, Fine J (May 1970). "A double-blind evaluation of capuride (Pacinox) as a presurgical aid to sleep". Current Therapeutic Research, Clinical and Experimental. 12 (5): 255–260. PMID 4986240.
↑ Weiss H (February 1971). "Capuride for sleep in rehabilitation patients: a controlled trial". Archives of Physical Medicine and Rehabilitation. 52 (2): 68–72. PMID 4927636.

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[Katz_1970-1] Katz J, Finestone SC, Pappas MT, Fine J (May 1970). "A double-blind evaluation of capuride (Pacinox) as a presurgical aid to sleep". Current Therapeutic Research, Clinical and Experimental. 12 (5): 255–260. PMID 4986240.

[2] Weiss H (February 1971). "Capuride for sleep in rehabilitation patients: a controlled trial". Archives of Physical Medicine and Rehabilitation. 52 (2): 68–72. PMID 4927636.

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