Divaplon

Divaplon

Clinical data
ATC code	none
Identifiers
IUPAC name (6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidin-2-yl)-phenylmethanone
CAS Number	90808-12-1  Y
PubChem CID	65822
ChemSpider	59234
UNII	4AOV43246G
ChEMBL	ChEMBL281164
CompTox Dashboard (EPA)	DTXSID40238269
Chemical and physical data
Formula	C17H17N3O2
Molar mass	295.342 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC1=C(N2C=C(N=C2N=C1OC)C(=O)C3=CC=CC=C3)C
InChI InChI=1S/C17H17N3O2/c1-4-13-11(2)20-10-14(18-17(20)19-16(13)22-3)15(21)12-8-6-5-7-9-12/h5-10H,4H2,1-3H3 Key:NRJVHCSYLGLURI-UHFFFAOYSA-N
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Divaplon (RU-32698) is a nonbenzodiazepine, anxiolytic and anticonvulsant drug from the imidazopyrimidine family of drugs. It acts as a partial agonist at the "benzodiazepine site" of the GABA_A receptor in the brain. ^{[1] [2] [3]}

References

1. Feely M, Boyland P, Picardo A, Cox A, Gent JP (May 1989). "Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812". European Journal of Pharmacology. 164 (2): 377–80. doi:10.1016/0014-2999(89)90482-2. PMID   2759183.
2. Sanger DJ, Joly D, Perrault G (September 1995). "Benzodiazepine (omega) receptor partial agonists and the acquisition of conditioned fear in mice". Psychopharmacology. 121 (1): 104–8. doi:10.1007/BF02245596. PMID   8539334. S2CID   32627339.
3. Pellón R, Ruíz A, Lamas E, Rodríguez C (February 2007). "Pharmacological analysis of the effects of benzodiazepines on punished schedule-induced polydipsia in rats". Behavioural Pharmacology. 18 (1): 81–7. doi:10.1097/FBP.0b013e3280143212. PMID   17218801. S2CID   40188048.