Scutellaria | |
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Scutellaria pekinensis | |
Scientific classification | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Eudicots |
Clade: | Asterids |
Order: | Lamiales |
Family: | Lamiaceae |
Subfamily: | Scutellarioideae |
Genus: | Scutellaria L. [1] |
Synonyms [1] | |
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Scutellaria is a genus of flowering plants in the mint family, Lamiaceae. They are known commonly as skullcaps. [2] The generic name is derived from the Latin scutella, meaning "a small dish, tray or platter", [3] or "little dish", [4] referring to the shape of the calyx. [4] The common name alludes to the resemblance of the same structure to "miniature medieval helmets". [4] The genus has a subcosmopolitan distribution, [5] with species occurring nearly worldwide, mainly in temperate regions. [6]
Most Scutellaria are annual or perennial herbaceous plants from 5 to 100 cm (2 to 39 in) tall, however a few are subshrubs. Some Scutellaria are aquatic. Scutellaria have four-angled stems and opposite leaves, and flowers with upper and lower lips. The genus is most easily recognized by the typical shield on the calyx that has also prompted its common name.
Skullcaps are used in traditional medicine, such as in traditional Chinese medicine. [7] The root of Scutellaria baicalensis – a common component of many preparations [8] – is marketed in volumes that have led to the overexploitation of the wild plant. Its rarity has led to an increase in price, and encouraged the adulteration of the product with other species of Scutellaria. [9]
In 1773, Scutellaria lateriflora became a common treatment in North America for the hysteria and hydrophobia caused by rabies. [10] Today it is still a popular medicinal herb. [11] It is widely available as a commercial product used in western herbalism. [12] The plant reportedly commands prices of $16 to $64 per pound dry weight. [13]
The main compounds in skullcap are flavonoids. [9] Isolated chemical compounds include wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyl flavanone found in Scutellaria. [14] Other constituents include baicalin, apigenin, oroxylin A, and scutellarein. [15]
Estimates of the number of species in the genus range from around 300 [4] [6] to about 350 [7] [16] or 360 [17] to 470. [5] [18] [2] [19] [20] [21] [22]
Selected species include:
The Lamiaceae or Labiatae are a family of flowering plants commonly known as the mint, deadnettle or sage family. Many of the plants are aromatic in all parts and include widely used culinary herbs like basil, mint, rosemary, sage, savory, marjoram, oregano, hyssop, thyme, lavender, and perilla, as well as other medicinal herbs such as catnip, salvia, bee balm, wild dagga, and oriental motherwort. Some species are shrubs, trees, or, rarely, vines. Many members of the family are widely cultivated, not only for their aromatic qualities, but also their ease of cultivation, since they are readily propagated by stem cuttings. Besides those grown for their edible leaves, some are grown for decorative foliage. Others are grown for seed, such as Salvia hispanica (chia), or for their edible tubers, such as Plectranthus edulis, Plectranthus esculentus, Plectranthus rotundifolius, and Stachys affinis. Many are also grown ornamentally, notably coleus, Plectranthus, and many Salvia species and hybrids.
Mentha is a genus of plants in the family Lamiaceae. The exact distinction between species is unclear; it is estimated that 13 to 24 species exist. Hybridization occurs naturally where some species' ranges overlap. Many hybrids and cultivars are known.
Artemisia vulgaris, the common mugwort, is a species of flowering plant in the daisy family Asteraceae. It is one of several species in the genus Artemisia commonly known as mugwort, although Artemisia vulgaris is the species most often called mugwort. It is also occasionally known as riverside wormwood, felon herb, chrysanthemum weed, wild wormwood, old Uncle Henry, sailor's tobacco, naughty man, old man, or St. John's plant. Mugworts have been used medicinally and as culinary herbs.
Clinopodium is a genus of flowering plants in the family Lamiaceae. It is in the tribe Mentheae of the subfamily Nepetoideae, but little else can be said with certainty about its phylogenetic position.
Scutellaria baicalensis, with the common name Baikal skullcap or Chinese skullcap, is a species of flowering plant in the family Lamiaceae.
Scutellaria lateriflora, is a hardy perennial herb of the mint family, Lamiaceae, native to North America.
Scutellaria galericulata, the common skullcap, marsh skullcap or hooded skullcap, is a hardy perennial herb native to northern areas of the Northern Hemisphere, including Europe, Asia, and almost all of Canada. It is a member of the mint family. The form is upright and is usually 20-45 centimeters in height, sometimes reaching up to 80 cm. It is a wetland-loving species and grows along fens and shorelines. The blue flowers are 1 to 2 centimeters long. The flowers are in pairs and are all on the same side of the stem. The flowers do not appear at the top of the stem.
As baicalin is a flavone glycoside, it is a flavonoid. It is the glucuronide of baicalein.
Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum and Thyme. It is the aglycone of baicalin. Baicalein is one of the active ingredients of Sho-Saiko-To, which is a Chinese classic herbal formula, and listed in Japan as Kampo medicine.
Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which is found in Scutellaria baicalensis.
Oroxylin A is an O-methylated flavone, a chemical compound that can be found in the medicinal plants Scutellaria baicalensis and Scutellaria lateriflora, and the Oroxylum indicum tree. It has demonstrated activity as a dopamine reuptake inhibitor, and is also a negative allosteric modulator of the benzodiazepine site of the GABAA receptor. Oroxylin A has been found to improve memory consolidation in mice by elevating brain-derived neurotrophic factor (BDNF) levels in the hippocampus.
Scutellarin is a flavone, a type of phenolic chemical compound. It can be found in the Asian "barbed skullcap" Scutellaria barbata and the north American plant S. lateriflora both of which have been used in traditional medicine. The compound is found only in trace amounts in the "Chinese skullcap" Scutellaria baicalensis, another plant used in traditional Chinese medicine.
Sclerocarpus is a genus of flowering plants in the tribe Heliantheae within the family Asteraceae. Bonebract is a common name for plants in this genus.
Anisomeles malabarica, more commonly known as the Malabar catmint, is a species of herbaceous shrub in the family Lamiaceae. It is native to tropical and subtropical regions of India, and Sri Lanka, but can also be found in Malaysia, Bangladesh, Myanmar, Bismarck Archipelago, Mauritius, Andaman Islands and Réunion.
Scutellaria minor, the lesser skullcap, is a species of flowering plant in the family Lamiaceae.
Baicalin-beta-D-glucuronidase (EC 3.2.1.167, baicalinase) is an enzyme with systematic name 5,6,7-trihydroxyflavone-7-O-beta-D-glucupyranosiduronate glucuronosylhydrolase. This enzyme catalyses the following chemical reaction
Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis. It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF).
Scutellaria multiglandulosa is a flowering plant in the genus Scutellariaand family Lamiaceae. It grows in parts of the Southeastern United States. It is sometimes referred to by the common name Small's skullcap.