Benzobarbital

Benzobarbital

Clinical data
Other names	Benzonal
ATC code	none
Identifiers
IUPAC name 1-benzoyl-5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
CAS Number	744-80-9  Y
PubChem CID	12938
ChemSpider	12402  Y
UNII	YNJ78BD0AH
ChEMBL	ChEMBL1338506  N
CompTox Dashboard (EPA)	DTXSID1046138
Chemical and physical data
Formula	C19H16N2O4
Molar mass	336.347 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCC1(C(=O)NC(=O)N(C1=O)C(=O)C2=CC=CC=C2)C3=CC=CC=C3
InChI InChI=1S/C19H16N2O4/c1-2-19(14-11-7-4-8-12-14)16(23)20-18(25)21(17(19)24)15(22)13-9-5-3-6-10-13/h3-12H,2H2,1H3,(H,20,23,25) Y Key:QMOWPJIFTHVQMB-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Benzobarbital (Benzonal) is a barbiturate derivative. It has anticonvulsant effects and has been used for the treatment of epilepsy. ^[1]

It has similar liver enzyme inducing effects to the closely related drug phenobarbital, which may be exploited in some clinical applications. ^{[2] [3]}

References

1. Okudzhava VM, Chankvetadze BG (1989). "[Pharmacological characteristics of an anti-convulsive drug Benzonal and the evaluation of its therapeutic effectiveness (review of the literature)]". Zhurnal Nevropatologii I Psikhiatrii imeni S.S. Korsakova (in Russian). 89 (11): 136–45. PMID   2696306.
2. Nadzhimutdinov KN, Khakimov ZZ, Kabulov S (1992). "[The advantages of benzonal as an inducer of the liver mono-oxygenase enzyme system compared to phenobarbital]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 55 (1): 68–71. PMID   1305441.
3. Novozheeva TP, Saratikov AS, Grishanova AI, Gutkina NI, Akhmedzhanov RR, Khatsenko OG, Kozlovskaia NE (February 1991). "[Benzonal--a phenobarbital-type of inducer of the mono-oxygenase system]". Biulleten' Eksperimental'noi Biologii I Meditsiny (in Russian). 111 (2): 163–5. OCLC   613807502. PMID   1854958.