Metaxalone

Last updated
Metaxalone
Metaxalone.svg
Clinical data
Trade names Skelaxin
AHFS/Drugs.com Monograph
MedlinePlus a682010
License data
Routes of
administration 		By mouth
ATC code
  • None
Legal status
Legal status
Pharmacokinetic data
Bioavailability Unknown
Metabolism Liver
Elimination half-life 9.2 ± 4.8 hours
Excretion Kidney
Identifiers
  • 5-[(3,5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.015.253 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C12H15NO3
Molar mass 221.256 g·mol−1
3D model (JSmol)
  • O=C2OC(COc1cc(cc(c1)C)C)CN2
  • InChI=1S/C12H15NO3/c1-8-3-9(2)5-10(4-8)15-7-11-6-13-12(14)16-11/h3-5,11H,6-7H2,1-2H3,(H,13,14) Yes check.svgY
  • Key:IMWZZHHPURKASS-UHFFFAOYSA-N Yes check.svgY
   (verify)

Metaxalone, sold under the brand name Skelaxin, is a muscle relaxant medication used to relax muscles and relieve pain caused by strains, sprains, and other musculoskeletal conditions. [1] Its exact mechanism of action is not known, but it may be due to general central nervous system depression. [1] It is a moderately strong muscle relaxant, with relatively low incidence of side effects.[ citation needed ]

Contents

Common side effects include nausea, vomiting, drowsiness, and central nervous system (CNS) side effects, such as dizziness, headache, and irritability. [1]

The metabolism of metaxalone involves enzymes CYP1A2 and CYP2C19 in the cytochrome P450 system. [ medical citation needed ] Because many medications are metabolized by enzymes in this system, precaution must be taken when administering it with other medications involving the P450 system to avoid interactions. [2]

Because of the potential for side effects, this drug is considered high risk in the elderly.[ medical citation needed ]

Pharmacokinetics

Metaxalone exhibits increased bioavailability when taken with food. [3] Specifically, in one study, compared to fasted conditions, the presence of food at the time of drug administration increased Cmax by 77.5%, AUC0-t by 23.5%, and AUC0-∞ by 15.4%. [4] Metaxalone is a substrate of CYP1A2 and CYP2C19, an inhibitor of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A, and an inducer of CYP1A2 and CYP3A4. [2]

Assay

A literature survey reveals very few methods are reported for the determination of metaxalone to date. Nirogi et al. [4] reported a liquid chromatographic method coupled to tandem mass spectrometry for the quantification of metaxalone in human plasma. A stability-indicating HPLC method was introduced by P.K. Sahu et al. [5] Metaxalone has been used as an internal standard for few analytical methods. [6] [7]

References

  1. 1 2 3 4 "Skelaxin- metaxalone tablet". DailyMed. U.S. National Library of Medicine. 27 April 2018. Retrieved 23 October 2020.
  2. 1 2 US 7378434,Du J, Roberts RH,"Metaxalone products, method of manufacture, and method of use",issued 27 May 2008, assigned to Takeda Pharmaceuticals USA Inc.
  3. ↑ "Skelaxin Package Insert". King Pharmaceuticals, Inc. Archived from the original on 9 March 2010.
  4. 1 2 Nirogi RV, Kandikere VN, Shukla M, Mudigonda K, Shrivastava W, Datla PV (May 2006). "Quantification of metaxalone in human plasma by liquid chromatography coupled to tandem mass spectrometry". Journal of Analytical Toxicology. 30 (4): 245–251. doi: 10.1093/jat/30.4.245 . PMID   16803662.
  5. ↑ Sahu PK, Annapurna MM, Kumar SD (2011). "Development and Validation of Stability Indicating RP-HPLC Method for the Determination of Metaxalone in Bulk and its Pharmaceutical Formulations". e-Journal of Chemistry. 8 (s1): S439 –S447. doi: 10.1155/2011/645710 .
  6. ↑ Mistri HN, Jangid AG, Pudage A, Gomes N, Sanyal M, Shrivastav P (June 2007). "High throughput LC-MS/MS method for simultaneous quantification of lamivudine, stavudine and nevirapine in human plasma". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 853 (1–2): 320–332. doi:10.1016/j.jchromb.2007.03.047. PMID   17481969.
  7. ↑ Mistri HN, Jangid AG, Pudage A, Shrivastav P (March 2008). "HPLC-ESI-MS/MS validated method for simultaneous quantification of zopiclone and its metabolites, N-desmethyl zopiclone and zopiclone-N-oxide in human plasma". Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 864 (1–2): 137–148. doi:10.1016/j.jchromb.2008.02.004. PMID   18313371.
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