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 Above: molecular structure of apronal Below: 3D representation of an apronal molecule | |
| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | |
| Pharmacokinetic data | |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| ChEMBL | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.007.677 |
| Chemical and physical data | |
| Formula | C9H16N2O2 |
| Molar mass | 184.239 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
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Apronal (brand name Sedormid), or apronalide, also known as allylisopropylacetylurea or allylisopropylacetylcarbamide, is a hypnotic/sedative drug of the ureide (acylurea) group synthesized in 1926 [1] by Hoffmann-La Roche. Though it is not a barbiturate, apronal is similar in structure to the barbiturates (being an open-chain carbamide instead of having a heterocyclic ring). [2] In accordance, it is similar in action to the barbiturates, although considerably milder in comparison (formerly used as a daytime sedative at doses of 1 to 2 grams every 3 to 4 hours). [2] Upon the finding that it caused patients to develop thrombocytopenic purpura, apronal was withdrawn from clinical use. [3]
Medicines with apronal are no longer used except in Japan. [3] Notably Australian Therapeutic Goods Administration issued a safety alert in May 2023 which prohibits the sale, supply and use of Japanese EVE-branded products in Australia [4] due to its dangerous side effects.