Cyclobarbital

Cyclobarbital

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral (tablets)
ATC code	N05CA10 ( WHO )
Legal status
Legal status	BR: Class B1 (Psychoactive drugs) [1] CA: Schedule IV DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B UN: Psychotropic Schedule III
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
IUPAC name 5-(1-cyclohexenyl)-5-ethyl-1,3-diazinane-2,4,6-trione
CAS Number	52-31-3  Y calcium:  143-76-0  Y
PubChem CID	5838
ChemSpider	5632  Y
UNII	0M8A98AD9H calcium:  0HZN7FV25R  Y
KEGG	D07323  N
ChEMBL	ChEMBL268164  Y
CompTox Dashboard (EPA)	DTXSID9022865
ECHA InfoCard	100.000.127
Chemical and physical data
Formula	C12H16N2O3
Molar mass	236.271 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C1NC(=O)NC(=O)C1(/C2=C/CCCC2)CC
InChI InChI=1S/C12H16N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h6H,2-5,7H2,1H3,(H2,13,14,15,16,17) Y Key:WTYGAUXICFETTC-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Cyclobarbital, cyclobarbitol or cyclobarbitone refers to a barbiturate derivative developed in the early 1970s in the Soviet Union. ^[2]

It was available in Russia until 2019, marketed and distributed as Reladorm, a fixed-dose combination pairing 100 mg cyclobarbital and 10 mg diazepam (a benzodiazepine anxiolytic, muscle relaxant, and anticonvulsant) indicated for treating insomnia before it was discontinued in 2019.

References

1. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
2. Breimer DD, Winten MA (March 1976). "Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration". European Journal of Clinical Pharmacology. 09 (5–6): 443–50. doi:10.1007/bf00606563. PMID   989475. S2CID   20271169.