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| Formula | C23H16F3N3O |
| Molar mass | 407.396 g·mol−1 |
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TP-003 is an anxiolytic drug with a novel chemical structure, which is used in scientific research. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic.
TP-003 is a positive allosteric modulator at the benzodiazepine binding site of GABAA receptors. [1] It possesses relative selectivity for benzodiazepine sites on α3-containing GABAA receptors, which are thought to contribute to the anxiolytic effects of benzodiazepines (in tandem with those containing α2 subunits). [2] It has modest anticonvulsant activity although less than that of diazepam. [3]
