Last updated

Clinical data
Trade names Navane
Other namesThiothixene (USAN US)
AHFS/Drugs.com Monograph
MedlinePlus a682867
  • AU:B1
Routes of
By mouth
Drug class Typical antipsychotic
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Metabolism Hepatic
Elimination half-life 10–20 hours
  • (9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard 100.233.356 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C23H29N3O2S2
Molar mass 443.62 g·mol−1
3D model (JSmol)
  • O=S(=O)(N(C)C)c2cc1C(\c3c(Sc1cc2)cccc3)=C/CCN4CCN(C)CC4
  • InChI=1S/C23H29N3O2S2/c1-24(2)30(27,28)18-10-11-23-21(17-18)19(20-7-4-5-9-22(20)29-23)8-6-12-26-15-13-25(3)14-16-26/h4-5,7-11,17H,6,12-16H2,1-3H3/b19-8- Yes check.svgY

Tiotixene, or thiothixene, sold under the brand name Navane among others, is a typical antipsychotic of the thioxanthene class which is related to chlorprothixene and is used in the treatment of psychoses like schizophrenia and bipolar mania. It was introduced in the United States in 1967 [1] by Pfizer. [2]


Tiotixene is also related to thioproperazine and pipotiazine, members of the phenothiazine class.



Tiotixene [3]
SiteKi (nM)SpeciesRef
SERT 3,162–3,878Human [3] [4]
NET 30,200Human [3] [4]
DAT 3,630Human [3] [4]
5-HT1A 410–912Human [3] [5] [4]
5-HT1B 151Human [3]
5-HT1D 659Human [3]
5-HT1E >10,000Human [3]
5-HT2A 50–89Human [5] [4]
5-HT2C 1,350–1,400Human [5] [4]
5-HT3 1,860Human [3] [4]
5-HT5A 361Human [3]
5-HT6 208–320Human [3] [5] [4]
5-HT7 15.5Human [3] [5] [4]
α1 19ND [4]
   α1A 11–12Human [3] [5]
   α1B 35Human [3]
α2 95ND [4]
   α2A 80Human [3] [5]
   α2B 50Human [3] [5]
   α2C 52Human [3] [5]
β1 >10,000Human [3]
β2 >10,000Human [3]
D1 51–339Human [3] [4]
D2 0.03–1.4Human [3] [5] [6]
D3 0.3–186Human [6] [4]
D4 203–363Human [3] [4]
D4.2 410–685Human [6]
D5 261Human [3]
H1 4.0–12Human [3] [5] [7]
H2 411Human [3]
H3 1,336Guinea pig [3]
H4 >10,000Human [3]
mACh 3,310ND [4]
   M1 ≥2,820Human [3] [4]
   M2 ≥2,450Human [3] [4]
   M3 ≥5,750Human [3] [5] [4]
   M4 >10,000Human [3]
   M5 5,376Human [3]
σ 1,780ND [4]
Values are Ki (nM). The smaller the value,
the more strongly the drug binds to the site.

Tiotixene acts primarily as a highly potent antagonist of the dopamine D2 and D3 receptors (subnanomolar affinity). [3] It is also an antagonist of the histamine H1, α1-adrenergic, and serotonin 5-HT7 receptors (low nanomolar affinity), as well as of various other receptors to a much lesser extent (lower affinity). [3] It does not have any anticholinergic activity. [3] Antagonism of the D2 receptor is thought to be responsible for the antipsychotic effects of tiotixene.


Tiotixene was introduced in 1967. [8] [9]


Tiotixene is a member of the thioxanthene class of antipsychotics. Analogues include chlorprothixene, clopenthixol, flupentixol, and zuclopenthixol.

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