|Other names||Thiothixene (USAN US)|
| Routes of|
|Drug class||Typical antipsychotic|
|Elimination half-life||10–20 hours|
|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||443.62 g·mol−1|
|3D model (JSmol)|
Tiotixene, or thiothixene, sold under the brand name Navane among others, is a typical antipsychotic of the thioxanthene class which is related to chlorprothixene and is used in the treatment of psychoses like schizophrenia and bipolar mania. It was introduced in the United States in 1967by Pfizer.
Tiotixene is also related to thioproperazine and pipotiazine, members of the phenothiazine class.
|Values are Ki (nM). The smaller the value,|
the more strongly the drug binds to the site.
Tiotixene acts primarily as a highly potent antagonist of the dopamine D2 and D3 receptors (subnanomolar affinity).It is also an antagonist of the histamine H1, α1-adrenergic, and serotonin 5-HT7 receptors (low nanomolar affinity), as well as of various other receptors to a much lesser extent (lower affinity). It does not have any anticholinergic activity. Antagonism of the D2 receptor is thought to be responsible for the antipsychotic effects of tiotixene.
Tiotixene was introduced in 1967.
Tiotixene is a member of the thioxanthene class of antipsychotics. Analogues include chlorprothixene, clopenthixol, flupentixol, and zuclopenthixol.
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It may be used by mouth and by injection into a muscle (IM). The IM form may be used for acute agitation in people with schizophrenia.
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