SKF-77,434

SKF-77,434

Identifiers
IUPAC name 3-allyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
CAS Number	104422-04-0
PubChem CID	1241
ChemSpider	1204  Y
UNII	XA99M7XZR5
ChEBI	CHEBI:63988
ChEMBL	ChEMBL288090
CompTox Dashboard (EPA)	DTXSID3043817
Chemical and physical data
Formula	C19H21NO2
Molar mass	295.382 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3ccccc3C2CN(CC=C)CCc(cc1O)c2cc1O
InChI InChI=1S/C19H21NO2/c1-2-9-20-10-8-15-11-18(21)19(22)12-16(15)17(13-20)14-6-4-3-5-7-14/h2-7,11-12,17,21-22H,1,8-10,13H2 Key:QBUVZVXIRYFENV-UHFFFAOYSA-N
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SKF-77,434 is a drug which acts as a selective dopamine D₁ receptor partial agonist, and has stimulant and anorectic effects. Unlike other D₁ agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction. ^{[1] [2] [3] [4] [5] [6] [7]}

See also

• Substituted 3-benzazepine

References

1. Grech DM, Spealman RD, Bergman J (May 1996). "Self-administration of D1 receptor agonists by squirrel monkeys". Psychopharmacology. 125 (2): 97–104. doi:10.1007/BF02249407. PMID   8783382. S2CID   36378721.
2. Weed MR, Paul IA, Dwoskin LP, Moore SE, Woolverton WL (October 1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29–38. PMID   9336305.
3. Platt DM, Rowlett JK, Spealman RD (June 2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017–26. PMID   10869406.
4. Platt DM, Rowlett JK, Spealman RD (September 2001). "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology. 157 (2): 208–16. doi:10.1007/s002130100779. PMID   11594448. S2CID   6567384.
5. Mutschler NH, Bergman J (April 2002). "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology. 160 (4): 362–70. doi:10.1007/s00213-001-0976-z. PMID   11919663. S2CID   20483120.
6. Desai RI, Terry P, Katz JL (August 2005). "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior. 81 (4): 843–8. doi:10.1016/j.pbb.2005.06.006. PMID   16000217. S2CID   2525256.
7. Katz JL, Kopajtic TA, Terry P (June 2006). "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology. 17 (4): 303–9. doi:10.1097/01.fbp.0000205015.67079.f7. PMID   16914948. S2CID   24288989.