Clebopride

Clebopride
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	A03FA06 ( WHO );
Identifiers
	IUPAC name 4-amino-N-(1-benzylpiperidin-4-yl)-5-chloro-; 2-methoxybenzamide;
CAS Number	55905-53-8 ;
PubChem CID	2780 ;
ChemSpider	2678 ;
UNII	I0A84520Y9 ;
KEGG	D03534 ;
ChEMBL	ChEMBL325109 ;
CompTox Dashboard (EPA)	DTXSID7022831 ;
ECHA InfoCard	100.054.424
Chemical and physical data
Formula	C20H24ClN3O2
Molar mass	373.88 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES Clc1cc(c(OC)cc1N)C(=O)NC3CCN(Cc2ccccc2)CC3;
	InChI InChI=1S/C20H24ClN3O2/c1-26-19-12-18(22)17(21)11-16(19)20(25)23-15-7-9-24(10-8-15)13-14-5-3-2-4-6-14/h2-6,11-12,15H,7-10,13,22H2,1H3,(H,23,25) ; Key:BVPWJMCABCPUQY-UHFFFAOYSA-N ;
	(verify)

Last updated December 30, 2025

Clebopride is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders. Chemically, it is a substituted benzamide, closely related to metoclopramide.

A small Spanish study found that more adverse reactions are reported with clebopride than with metoclopramide, particularly extrapyramidal symptoms.^[1]

References

↑ Cuena Boy R, Maciá Martínez MA (March 1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]". Atencion Primaria (in Spanish). 21 (5): 289–95. PMID 9608114. Free full text Archived 2018-11-01 at the Wayback Machine

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[1] Cuena Boy R, Maciá Martínez MA (March 1998). "[Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]". Atencion Primaria (in Spanish). 21 (5): 289–95. PMID 9608114. Free full text Archived 2018-11-01 at the Wayback Machine

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