Papaverine

Last updated
Papaverine
Papaverine.svg
Papaverine-from-xtal-3D-balls-B.png
Clinical data
Pronunciation /pəˈpævəriːn/
Trade names Pavabid, others
AHFS/Drugs.com Monograph
MedlinePlus a682707
Pregnancy
category
  • AU:A
Routes of
administration 		Oral, intravenous, intramuscular, rectal, intracavernosal
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 80%
Protein binding ~90%
Metabolism Hepatic
Elimination half-life 1.5–2 hours
Excretion Renal
Identifiers
  • 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline
CAS Number
  • 58-74-2  Yes check.svgY
    61-25-6 (hydrochloride)
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.361 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C20H21NO4
Molar mass 339.391 g·mol−1
3D model (JSmol)
  • COc1ccc(cc1OC)Cc2c3cc(c(cc3ccn2)OC)OC
  • InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3 Yes check.svgY
  • Key:XQYZDYMELSJDRZ-UHFFFAOYSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Papaverine (Latin papaver , "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasms and vasospasms (especially those involving the intestines, heart, or brain), occasionally in the treatment of erectile dysfunction and acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic morphine and its derivatives (such as codeine).

Contents

In addition to opium, papaverine is purported to be present in high concentrations in star gooseberry. [1]

History

Capsule of Papaver somniferum showing latex (opium) exuding from incision. Papaverine occurs naturally in opium. Opium pod cut to demonstrate fluid extraction1.jpg
Capsule of Papaver somniferum showing latex (opium) exuding from incision. Papaverine occurs naturally in opium.

Papaverine was discovered in 1848 by Georg Merck (1825–1873). [2] Merck was a student of the German chemists Justus von Liebig and August Hofmann, and he was the son of Emanuel Merck (1794–1855), founder of the Merck corporation, a major German chemical and pharmaceutical company. [3]

Uses

Papaverine is approved to treat spasms of the gastrointestinal tract, bile ducts and ureter and for use as a cerebral and coronary vasodilator in subarachnoid hemorrhage (combined with balloon angioplasty) [4] and coronary artery bypass surgery. [5] Papaverine may also be used as a smooth muscle relaxant in microsurgery where it is applied directly to blood vessels.

Papaverine is used as an erectile dysfunction drug, alone or sometimes in combination. [6] [7] Papaverine, when injected in penile tissue, causes direct smooth muscle relaxation and consequent filling of the corpus cavernosum with blood resulting in erection. A topical gel is also available for ED treatment. [8]

It is also commonly used in cryopreservation of blood vessels along with the other glycosaminoglycans and protein suspensions. [9] [10] Functions as a vasodilator during cryopreservation when used in conjunction with verapamil, phentolamine, nifedipine, tolazoline or nitroprusside. [11] [12]

Papaverine is also being investigated as a topical growth factor in tissue expansion with some success. [13]

Papaverine is used as an off-label prophylaxis (preventative) of migraine headaches. [14] [15] [16] It is not a first line drug such as a few beta blockers, calcium channel blockers, tricyclic antidepressants, and some anticonvulsants such as divalproex, but rather when these first line drugs and secondary drugs such as SSRIs, angiotensin II receptor antagonists, etc. fail in the prophylaxis of migraines, have intolerable side effects or are contraindicated.

Papaverine is also present in combinations of opium alkaloid salts such as papaveretum (Omnopon, Pantopon) and others, along with morphine, codeine, and in some cases noscapine and others in a percentage similar to that in opium, or modified for a given application.

Papaverine is found as a contaminant in some heroin [17] and can be used by forensic laboratories in heroin profiling to identify its source. [18] The metabolites can also be found in the urine of heroin users, allowing street heroin to be distinguished from pharmaceutical diacetylmorphine. [19]

Mechanism

The in vivo mechanism of action is not entirely clear, but an inhibition of the enzyme phosphodiesterase causing elevation of cyclic AMP and cyclic GMP[ clarification needed ] levels is significant. It may also alter mitochondrial respiration.

Papaverine has also been demonstrated to be a selective phosphodiesterase inhibitor for the PDE10A subtype found mainly in the striatum of the brain. When administered chronically to mice, it produced motor and cognitive deficits and increased anxiety, but conversely may produce an antipsychotic effect, [20] [21] although not all studies support this view. [22]

Side effects

Frequent side effects of papaverine treatment include polymorphic ventricular tachycardia, constipation, interference with sulphobromophthalein [ citation needed ] retention test (used to determine hepatic function), increased transaminase levels, increased alkaline phosphatase levels, somnolence, and vertigo.

Rare side effects include flushing of the face, hyperhidrosis (excessive sweating), cutaneous eruption, arterial hypotension, tachycardia, loss of appetite, jaundice, eosinophilia, thrombopenia, mixed hepatitis, headache, allergic reaction, chronic active hepatitis, and paradoxical aggravation of cerebral vasospasm. [23]

Papaverine in the plant Sauropus androgynus is linked to bronchiolitis obliterans. [24]

Formulations and trade names

Papaverine is available in its salt form as the hydrochloride, codecarboxylate, adenylate, and teprosylate. It was also once available as a salt of hydrobromide, camsylate, cromesilate, nicotinate, and phenylglycolate. The hydrochloride salt is available for intramuscular, intravenous, rectal and oral administration. The teprosylate is available in intravenous, intramuscular, and orally administered formulations. The codecarboxylate is available in oral form, only, as is the adenylate.

The codecarboxylate is sold under the name Albatran,[ citation needed ] the adenylate as Dicertan,[ citation needed ] and the hydrochloride salt is sold variously as Artegodan (Germany), Cardioverina (countries outside Europe and the United States), Dispamil (countries outside Europe and the United States), Opdensit (Germany), Panergon (Germany), Paverina Houde (Italy, Belgium), Pavacap (United States), Pavadyl (United States), Papaverine (Israel), Papaverin-Hamelin (Germany), Paveron (Germany), Spasmo-Nit (Germany), Cardiospan, Papaversan, Cepaverin, Cerespan, Drapavel, Forpaven, Papalease, Pavatest, Paverolan, Therapav (Canada [25] ), Vasospan, Cerebid, Delapav, Dilaves, Durapav, Dynovas, Optenyl, Pameion, Papacon, Pavabid, Pavacen, Pavakey, Pavased, Pavnell, Alapav, Myobid, Vasal, Pamelon, Pavadel, Pavagen, Ro-Papav, Vaso-Pav, Papanerin-hcl, Qua bid, Papital T.R., Paptial T.R., Pap-Kaps-150.[ citation needed ] In Hungary, papaverine and homatropine methylbromide are used in mild drugs that help "flush" the bile. [26]

Related Research Articles

<span class="mw-page-title-main">Morphine</span> Pain medication of the opiate family

Morphine is a strong opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies. It is mainly used as an analgesic. There are numerous methods used to administer morphine: oral; sublingual; via inhalation; injection into a muscle, injection under the skin, or injection into the spinal cord area; transdermal; or via rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor. Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3–7 hours. Long-acting formulations of morphine are available as MS-Contin, Kadian, and other brand names as well as generically.

<span class="mw-page-title-main">Opium</span> Dried latex obtained from the opium poppy

Opium is dried latex obtained from the seed capsules of the opium poppy Papaver somniferum. Approximately 12 percent of opium is made up of the analgesic alkaloid morphine, which is processed chemically to produce heroin and other synthetic opioids for medicinal use and for the illegal drug trade. The latex also contains the closely related opiates codeine and thebaine, and non-analgesic alkaloids such as papaverine and noscapine. The traditional, labor-intensive method of obtaining the latex is to scratch ("score") the immature seed pods (fruits) by hand; the latex leaks out and dries to a sticky yellowish residue that is later scraped off and dehydrated. The word meconium historically referred to related, weaker preparations made from other parts of the opium poppy or different species of poppies.

<span class="mw-page-title-main">Phosphodiesterase inhibitor</span> Drug

A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s). The ubiquitous presence of this enzyme means that non-specific inhibitors have a wide range of actions, the actions in the heart, and lungs being some of the first to find a therapeutic use.

<span class="mw-page-title-main">Sildenafil</span> Drug for erectile dysfunction and hypertension

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<span class="mw-page-title-main">Subarachnoid hemorrhage</span> Bleeding into the subarachnoid space

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<span class="mw-page-title-main">Methysergide</span> Chemical compound

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References

  1. ↑ Kao CH; Ho YJ; Wu CL; ChangLai SP (1999). "Using 99mTc-DTPA Radioaerosol Inhalation Lung Scintigraphies to Detect the Lung Injury Induced by Consuming Sauropus androgynus Vegetable and Comparison with Conventional Pulmonary Function Tests". Respiration. Karger AG. 66 (1): 46–51. doi:10.1159/000029336. PMID   9973690. S2CID   38378580.
  2. ↑ Merck G (1848). "Vorläufige Notiz über eine neue organische Base im Opium" [Preliminary notice of a new organic base in opium]. Annalen der Chemie und Pharmacie. 66: 125–128. doi:10.1002/jlac.18480660121.
  3. ↑ Brock WH (2002-06-20). Justus Von Liebig: The Chemical Gatekeeper. Cambridge University Press. p. 120. ISBN   978-0-521-52473-5.
  4. ↑ Liu JK, Couldwell WT (2005). "Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage". Neurocritical Care. 2 (2): 124–132. doi:10.1385/NCC:2:2:124. PMID   16159054. S2CID   35400205.
  5. ↑ Takeuchi K, Sakamoto S, Nagayoshi Y, Nishizawa H, Matsubara J (November 2004). "Reactivity of the human internal thoracic artery to vasodilators in coronary artery bypass grafting". European Journal of Cardio-Thoracic Surgery. 26 (5): 956–959. doi: 10.1016/j.ejcts.2004.07.047 . PMID   15519189.
  6. ↑ Desvaux P (July 2005). "[An overview of the management of erectile disorders]". Presse Médicale. 34 (13 Suppl): 5–7. PMID   16158020.
  7. ↑ Bella AJ, Brock GB (2004). "Intracavernous pharmacotherapy for erectile dysfunction". Endocrine. 23 (2–3): 149–155. doi:10.1385/ENDO:23:2-3:149. PMID   15146094. S2CID   13056029.
  8. ↑ Kim ED, el-Rashidy R, McVary KT (February 1995). "Papaverine topical gel for treatment of erectile dysfunction". The Journal of Urology. 153 (2): 361–365. doi:10.1097/00005392-199502000-00019. PMID   7815584.
  9. ↑ Müller-Schweinitzer E, Ellis P (May 1992). "Sucrose promotes the functional activity of blood vessels after cryopreservation in DMSO-containing fetal calf serum". Naunyn-Schmiedeberg's Archives of Pharmacology. 345 (5): 594–597. doi:10.1007/bf00168954. PMID   1528275. S2CID   10441842.
  10. ↑ Müller-Schweinitzer E, Hasse J, Swoboda L (1993). "Cryopreservation of human bronchi". The Journal of Asthma. 30 (6): 451–457. doi:10.3109/02770909309056754. PMID   8244915.
  11. ↑ Brockbank KG (February 1994). "Effects of cryopreservation upon vein function in vivo". Cryobiology. 31 (1): 71–81. doi:10.1006/cryo.1994.1009. PMID   8156802.
  12. ↑ Giglia JS, Ollerenshaw JD, Dawson PE, Black KS, Abbott WM (November 2002). "Cryopreservation prevents arterial allograft dilation". Annals of Vascular Surgery. 16 (6): 762–767. doi:10.1007/s10016-001-0072-1. PMID   12391500. S2CID   24777062.
  13. ↑ Tang Y, Luan J, Zhang X (October 2004). "Accelerating tissue expansion by application of topical papaverine cream". Plastic and Reconstructive Surgery. 114 (5): 1166–1169. doi:10.1097/01.PRS.0000135854.48570.76. PMID   15457029.
  14. ↑ Sillanpää M, Koponen M (March 1978). "Papaverine in the prophylaxis of migraine and other vascular headache in children". Acta Paediatrica Scandinavica. 67 (2): 209–212. doi:10.1111/j.1651-2227.1978.tb16304.x. PMID   343489. S2CID   28817628.
  15. ↑ Vijayan N (September 1977). "Brief therapeutic report: papaverine prophylaxis of complicated migraine". Headache. 17 (4): 159–162. doi:10.1111/j.1526-4610.1977.hed1704159.x. PMID   893088. S2CID   36626189.
  16. ↑ Poser CM (June 1974). "Letter: Papaverine in prophylactic treatment of migraine". Lancet. 1 (7869): 1290. doi:10.1016/S0140-6736(74)90045-2. PMID   4134173.
  17. ↑ Paterson S, Cordero R (May 2006). "Comparison of the various opiate alkaloid contaminants and their metabolites found in illicit heroin with 6-monoacetyl morphine as indicators of heroin ingestion". Journal of Analytical Toxicology. 30 (4): 267–273. doi: 10.1093/jat/30.4.267 . PMID   16803666. In addition to morphine, street heroin contains various alkaloids extracted from the opium poppy, Papaversomniferum, including codeine, thebaine, noscapine, and papaverine
  18. ↑ Seetohul LN, Maskell PD, De Paoli G, Pounder DJ (March 2013). "Biomarkers for illicit heroin: a previously unrecognized origin of papaverine". Journal of Analytical Toxicology. 37 (2): 133. doi: 10.1093/jat/bks099 . PMID   23316026.
  19. ↑ Strang J, Metrebian N, Lintzeris N, Potts L, Carnwath T, Mayet S, et al. (May 2010). "Supervised injectable heroin or injectable methadone versus optimised oral methadone as treatment for chronic heroin addicts in England after persistent failure in orthodox treatment (RIOTT): a randomised trial". Lancet. 375 (9729): 1885–1895. doi:10.1016/s0140-6736(10)60349-2. PMID   20511018. S2CID   205958031.
  20. ↑ Siuciak JA, Chapin DS, Harms JF, Lebel LA, McCarthy SA, Chambers L, et al. (August 2006). "Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis". Neuropharmacology. 51 (2): 386–396. doi:10.1016/j.neuropharm.2006.04.013. PMID   16780899. S2CID   13447370.
  21. ↑ Hebb AL, Robertson HA, Denovan-Wright EM (May 2008). "Phosphodiesterase 10A inhibition is associated with locomotor and cognitive deficits and increased anxiety in mice". European Neuropsychopharmacology. 18 (5): 339–363. doi:10.1016/j.euroneuro.2007.08.002. PMID   17913473. S2CID   9621541.
  22. ↑ Weber M, Breier M, Ko D, Thangaraj N, Marzan DE, Swerdlow NR (May 2009). "Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine". Psychopharmacology. 203 (4): 723–735. doi:10.1007/s00213-008-1419-x. PMC   2748940 . PMID   19066855.
  23. ↑ Clyde BL, Firlik AD, Kaufmann AM, Spearman MP, Yonas H (April 1996). "Paradoxical aggravation of vasospasm with papaverine infusion following aneurysmal subarachnoid hemorrhage. Case report". Journal of Neurosurgery. 84 (4): 690–695. doi:10.3171/jns.1996.84.4.0690. PMID   8613866. S2CID   1172874.
  24. ↑ Bunawan H, Bunawan SN, Baharum SN, Noor NM (2015). "Sauropus androgynus (L.) Merr. Induced Bronchiolitis Obliterans: From Botanical Studies to Toxicology". Evidence-Based Complementary and Alternative Medicine. 2015: 714158. doi: 10.1155/2015/714158 . PMC   4564651 . PMID   26413127.
  25. ↑ "THERAPAV (PRODUIT PUR) - Détail" . Retrieved 26 September 2005. CSST - Service du répertoire toxicologique. (French)
  26. ↑ "Országos Gyógyszerészeti és Élelmezés-egészségügyi Intézet". www.ogyi.hu. Archived from the original on 2015-01-23. Retrieved 2008-10-14.
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