T-0156

Last updated
T-0156
T-0156.svg
Names
Preferred IUPAC name
Methyl 2-[(2-methylpyridin-4-yl)methyl]-1-oxo-8-[(pyrimidin-2-yl)methoxy]-4-(3,4,5-trimethoxyphenyl)-1,2-dihydro-2,7-naphthyridine-3-carboxylate
Other names
T0156
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
PubChem CID
  • InChI=1S/C31H29N5O7/c1-18-13-19(7-11-32-18)16-36-27(31(38)42-5)25(20-14-22(39-2)28(41-4)23(15-20)40-3)21-8-12-35-29(26(21)30(36)37)43-17-24-33-9-6-10-34-24/h6-15H,16-17H2,1-5H3
    Key: JEMJAABFSYOLAP-UHFFFAOYSA-N
  • (HCl):InChI=1S/C31H29N5O7.ClH/c1-18-13-19(7-11-32-18)16-36-27(31(38)42-5)25(20-14-22(39-2)28(41-4)23(15-20)40-3)21-8-12-35-29(26(21)30(36)37)43-17-24-33-9-6-10-34-24;/h6-15H,16-17H2,1-5H3;1H
    Key: RBJCBXAXUHCWBR-UHFFFAOYSA-N
  • CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC
  • (HCl):CC1=NC=CC(=C1)CN2C(=C(C3=C(C2=O)C(=NC=C3)OCC4=NC=CC=N4)C5=CC(=C(C(=C5)OC)OC)OC)C(=O)OC.Cl
Properties
C31H29N5O7
Molar mass 583.601 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

T-0156 is a phosphodiesterase 5 inhibitor. [1] [2]

References

  1. ↑ Parlak, A; Yildirim, S; Bagcivan, I; Durmus, N (October 2012). "Role of New Agents Affecting NO/cGMP Pathway on Ovalbumin-Sensitized Guinea Pig Trachea". Experimental Lung Research. 38 (8): 420–6. doi:10.3109/01902148.2012.719281. PMID   23030645. S2CID   22720639.
  2. ↑ Santos, AI; Carreira, BP; Nobre, RJ; Carvalho, CM; Araújo, IM (2014). "Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5". Stem Cells International. 2014 878397. doi: 10.1155/2014/878397 . PMC   3914480 . PMID   24550991.


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