Propentofylline

Propentofylline

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N06BC02 ( WHO ) QC04AD90 ( WHO )
Identifiers
IUPAC name 3-methyl-1-(5-oxohexyl)-7-propyl-3,7-dihydro-1H-purine-2,6-dione
CAS Number	55242-55-2  Y
PubChem CID	4938
ChemSpider	4769
UNII	5RTA398U4H
CompTox Dashboard (EPA)	DTXSID4045189
ECHA InfoCard	100.133.568
Chemical and physical data
Formula	C15H22N4O3
Molar mass	306.366 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCCn1cnc2c1c(=O)n(c(=O)n2C)CCCCC(=O)C
InChI InChI=1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3 Key:RBQOQRRFDPXAGN-UHFFFAOYSA-N
(verify)

Propentofylline (HWA 285) is a xanthine derivative drug with purported neuroprotective effects.

Pharmacology

It is a phosphodiesterase inhibitor, ^[1] and also acts as an adenosine reuptake inhibitor. ^{[1] [2] [3]}

Uses

Propentofylline was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia, ^{[1] [4]} and has been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties. ^{[5] [6]}

Propentofylline is in use as a veterinary medicine in older dogs. ^[7]

See also

• Pentoxifylline

External links

• Summary of research, including possible multipartite mechanisms

References

1. Frampton M, Harvey RJ, Kirchner V (2003). Frampton MA (ed.). "Propentofylline for dementia". The Cochrane Database of Systematic Reviews (2): CD002853. doi:10.1002/14651858.CD002853. PMID   12804440.
2. Salimi S, Fotouhi A, Ghoreishi A, Derakhshan MK, Khodaie-Ardakani MR, Mohammadi MR, et al. (April 2008). "A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia". Progress in Neuro-Psychopharmacology & Biological Psychiatry. 32 (3): 726–732. doi:10.1016/j.pnpbp.2007.11.021. PMID   18096287. S2CID   21498202.
3. Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M (June 1998). "Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet". Neuroscience. 84 (4): 1127–1133. doi: 10.1016/S0306-4522(97)00542-3 . PMID   9578400. S2CID   36155779.
4. Kittner B, Rössner M, Rother M (September 1997). "Clinical trials in dementia with propentofylline". Annals of the New York Academy of Sciences. 826 (1): 307–316. Bibcode:1997NYASA.826..307K. doi:10.1111/j.1749-6632.1997.tb48481.x. PMID   9329701. S2CID   12493243.
5. Bath PM, Bath-Hextall FJ (2004). Bath PM (ed.). "Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke". The Cochrane Database of Systematic Reviews (3): CD000162. doi:10.1002/14651858.CD000162.pub2. PMID   15266424.
6. Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD (May 1993). "Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke". Journal of Cerebral Blood Flow and Metabolism. 13 (3): 526–530. doi:10.1038/jcbfm.1993.68. PMID   8478410. S2CID   24909748.
7. "Launch of tablet to make life easier for dogs in old age". Yorkshire Post. 7 September 2012. Retrieved 28 December 2019.