Cafedrine

Last updated

Cafedrine
Cafedrine Structure.svg
Clinical data
Trade names Akrinor, Bifort, Praxinor
Other namesCaphedrine; Cafedrin; Caphedrin; Kafedrin; Norephedrino-ethyltheophylline; 7-(2-(β-Hydroxy-α-methylphen-ethylamino)ethyl)theophylline
ATC code
Identifiers
  • (RS)-7-[2-[(1-hydroxy-1-phenylpropan-2-yl)amino]ethyl]-1,3-dimethylpurine-2,6-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C18H23N5O3
Molar mass 357.414 g·mol−1
3D model (JSmol)
  • C(CN[C@H]([C@H](O)C1=CC=CC=C1)C)N2C3=C(N(C)C(=O)N(C)C3=O)N=C2
  • InChI=1S/C18H23N5O3/c1-12(15(24)13-7-5-4-6-8-13)19-9-10-23-11-20-16-14(23)17(25)22(3)18(26)21(16)2/h4-8,11-12,15,19,24H,9-10H2,1-3H3/t12-,15-/m0/s1 Yes check.svgY
  • Key:UJSKUDDDPKGBJY-WFASDCNBSA-N Yes check.svgY
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Cafedrine (INN Tooltip International Nonproprietary Name, BAN Tooltip British Approved Name), sold under the brand name Akrinor among others, is a chemical linkage of norephedrine and theophylline and is a cardiac stimulant and antihypotensive agent used to increase blood pressure in people with hypotension. [1] [2] [3] [4] It has been marketed in Europe, South Africa, and Indonesia. [4] [5]

There has been concern about cafedrine as a potential performance-enhancing drug and doping agent in sports. [6]

See also

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References

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  2. Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. 2013. p. 785. ISBN   978-0-8155-1856-3 . Retrieved 29 August 2024.
  3. Morton IK, Hall JM (1999). "Calcitonin gene-related peptide receptor antagonist". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 59. ISBN   9789401144391.
  4. 1 2 Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Index nominum. Medpharm Scientific Publishers. p. 157. ISBN   978-3-88763-075-1 . Retrieved 29 August 2024.
  5. "Cafedrine". Drugs.com. Retrieved 29 August 2024.
  6. Wilson W, Derse E (2001). Doping in Elite Sport: The Politics of Drugs in the Olympic Movement. Human Kinetics. p. 15. ISBN   978-0-7360-0329-2 . Retrieved 29 August 2024.