Acefylline

Acefylline

Clinical data
Routes of administration	Intramuscular, Intravenous
ATC code	R03DA09 ( WHO )(acefylline piperazine)
Identifiers
IUPAC name (1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)acetic acid
CAS Number	652-37-9  N
PubChem CID	69550
ChemSpider	62754  Y
UNII	M494UE2YEP
ChEMBL	ChEMBL70246  Y
CompTox Dashboard (EPA)	DTXSID6057796
ECHA InfoCard	100.010.447
Chemical and physical data
Formula	C9H10N4O4
Molar mass	238.203 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2N(c1ncn(c1C(=O)N2C)CC(=O)O)C
InChI InChI=1S/C9H10N4O4/c1-11-7-6(8(16)12(2)9(11)17)13(4-10-7)3-5(14)15/h4H,3H2,1-2H3,(H,14,15) Y Key:HCYFGRCYSCXKNQ-UHFFFAOYSA-N Y
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Acefylline (INN), ^[1] also known as 7-theophyllineacetic acid, is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation etanautine to help offset diphenhydramine induced drowsiness. ^[2]

A silanol–mannuronic acid conjugate of acefylline, acefylline methylsilanol mannuronate (INCI; trade name Xantalgosil C) is marketed as a lipolytic phosphodiesterase inhibitor. It is used as an ingredient in cosmeceuticals for the treatment of cellulite and as a skin conditioner. ^{[3] [4]}

See also

• 8-Chlorotheophylline
• Theophylline
• Caffeine

References

1. "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names (Rec. INN): List 21" (PDF). World Health Organization. Retrieved 29 December 2016.
2. Zuidema J (1978). "Biofarmaceutische en farmacokinetische aspecten van theofylline en acefylline". Thesis (doctoral)--Universiteit van Amsterdam. Retrieved 2012-09-29.^{[ dead link ]}
3. Biosil Technologies (2005). "Xantalgosil C® Datasheet" (PDF). Exsymol S.A.M. Retrieved 2022-01-20.
4. Winter, Ruth (2009-10-20). A Consumer's Dictionary of Cosmetic Ingredients (7th ed.). Harmony/Rodale. p. 42. ISBN   9780307459862.