Adenosine reuptake inhibitor

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Adenosine

An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters (ENTs). [1] [2] [3] This in turn leads to increased extracellular concentrations of adenosine and therefore an increase in adenosinergic neurotransmission.

Contents

List of AdoRIs

See also

References

  1. 1 2 3 4 SenGupta DJ, Unadkat JD (2004). "Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep". Biochem Pharmacol. 67 (3): 453–458. doi:10.1016/j.bcp.2003.09.018. PMID   15037197.
  2. ↑ Endres CJ, Sengupta DJ, Unadkat JD (2004). "Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1". Biochem J. 380 (1): 131–137. doi:10.1042/BJ20031880. PMC   1224139 . PMID   14759222.
  3. ↑ Chaudary N, Naydenova Z, Shuralyova I, Coe IR (2004). "The adenosine transporter, mENT1, is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1". J Pharmacol Exp Ther. 310 (3): 1190–1198. doi:10.1124/jpet.104.067157. PMID   15131243. S2CID   21804556.
  4. 1 2 3 4 5 6 Goldfrank LR, Neal Flomenbaum, Mary Ann Howland, Robert S. (2006). Goldfrank's toxicologic emergencies . p.  243.
  5. 1 2 3 Narimatsu E, Niiya T, Kawamata M, Namiki A (2006). "[The mechanisms of depression by benzodiazepines, barbiturates and propofol of excitatory synaptic transmissions mediated by adenosine neuromodulation]". Masui. 55 (6): 684–691. PMID   16780077.
  6. ↑ Tohdoh Y, Narimatsu E, Kawamata M, Namiki A (2000). "The involvement of adenosine neuromodulation in pentobarbital-induced field excitatory postsynaptic potentials depression in rat hippocampal slices". Anesth Analg. 91 (6): 1537–1541. doi:10.1097/00000539-200012000-00044. PMID   11094014.
  7. ↑ Patel J, Marangos PJ, Skolnick P, Paul SM, Martino AM (1982). "Benzodiazepines are weak inhibitors of [3H]nitrobenzylthioinosine binding to adenosine uptake sites in brain". Neurosci Lett. 29 (1): 79–82. doi:10.1016/0304-3940(82)90368-8. PMID   7070715. S2CID   39089007.
  8. ↑ York MJ, Davies LP (1982). "The effect of diazepam on adenosine uptake and adenosine-stimulated adenylate cyclase in guinea-pig brain". Can J Physiol Pharmacol . 60 (3): 302–307. doi:10.1139/y82-041. PMID   6280826.
  9. ↑ Ujfalusi A, Cseppentö A, Nagy E, Szabó JZ, Kovács P, Szentmiklósi AJ (1999). "Sensitization by chronic diazepam treatment of A2A adenosine receptor-mediated relaxation in rat pulmonary artery". Life Sci. 64 (2): PL19–25. doi:10.1016/S0024-3205(98)00547-5. PMID   10069495.
  10. ↑ Narimatsu E, Niiya T, Kawamata M, Namiki A (2008). "Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms". Acta Anaesthesiol Scand. 52 (10): 1415–1422. doi:10.1111/j.1399-6576.2008.01714.x. PMID   19025536. S2CID   21837865.
  11. ↑ Bender AS, Hertz L (1986). "Similarities of adenosine uptake systems in astrocytes and neurons in primary cultures". Neurochem Res. 11 (11): 1507–1524. doi:10.1007/BF00965770. PMID   2891057. S2CID   8585637.
  12. ↑ O'Regan MH, Phillis JW (1988). "Potentiation of adenosine-evoked depression of rat cerebral cortical neurons by triazolam". Brain Res. 445 (2): 376–379. doi:10.1016/0006-8993(88)91203-6. PMID   3370471. S2CID   33550022.
  13. 1 2 Phillis JW, Delong RE (1984). "A purinergic component in the central actions of meprobamate". Eur J Pharmacol. 101 (3–4): 295–297. doi:10.1016/0014-2999(84)90174-2. PMID   6468504.
  14. 1 2 DeLong RE, Phillis JW, Barraco RA (1985). "A possible role of endogenous adenosine in the sedative action of meprobamate". Eur J Pharmacol. 118 (3): 359–362. doi:10.1016/0014-2999(85)90149-9. PMID   4085561.
  15. ↑ Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH (2009). "[Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies". J Pharmacol Exp Ther. 329 (2): 827–837. doi:10.1124/jpet.109.151142. PMC   2672873 . PMID   19244096.
  16. ↑ Wang S, Cone J, Fong M, Yoshitake M, Kambayashi Ji, Liu Y (2001). "Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication". J Cardiovasc Pharmacol. 38 (5): 775–783. doi: 10.1097/00005344-200111000-00014 . PMID   11602824.
  17. 1 2 3 4 5 Phillis JW, Wu PH (1982). "The effect of various centrally active drugs on adenosine uptake by the central nervous system". Comp Biochem Physiol C. 72 (2): 179–187. doi:10.1016/0306-4492(82)90082-X. PMID   6128137.
  18. 1 2 Phillis J.W. (1984). "Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants". Br J Pharmacol. 83 (2): 567–575. doi:10.1111/j.1476-5381.1984.tb16521.x. PMC   1987110 . PMID   6487906.
  19. ↑ Stein MB, Black B, Brown TM, Uhde TW (1993). "Lack of efficacy of the adenosine reuptake inhibitor dipyridamole in the treatment of anxiety disorders". Biol Psychiatry. 33 (8–9): 647–650. doi:10.1016/0006-3223(93)90105-M. PMID   8329495. S2CID   54364716.
  20. 1 2 Phillis JW, Bender AS, Marszalec W (1985). "Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons". Gen Pharmacol. 16 (6): 609–612. doi:10.1016/0306-3623(85)90151-x. PMID   2935451.
  21. ↑ Allen-Gipson DS, Jarrell JC, Bailey KL, Robinson JE, Kharbanda KK, Sisson JH, Wyatt TA (2009). "Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells". Alcohol Clin Exp Res. 33 (5): 791–8. doi:10.1111/j.1530-0277.2009.00897.x. PMC   2940831 . PMID   19298329.
  22. ↑ Verma A, Houston M, Marangos PJ (1985). "Solubilization of an adenosine uptake site in brain". J Neurochem. 45 (2): 596–603. doi:10.1111/j.1471-4159.1985.tb04028.x. PMID   2989430. S2CID   42431981.
  23. 1 2 Phillis JW, Wu PH, Coffin VL (1983). "Inhibition of adenosine uptake into rat brain synaptosomes by prostaglandins, benzodiazepines and other centrally active compounds". Gen Pharmacol. 14 (5): 475–479. doi:10.1016/0306-3623(83)90106-4. PMID   6416920.
  24. ↑ Ngai AC, Monsen MR, Ibayashi S, Ko KR, Winn HR (1989). "Effect of inosine on pial arterioles: potentiation of adenosine-induced vasodilation". Am J Physiol. 256 (3 (Pt2)): H603 –H606. doi:10.1152/ajpheart.1989.256.3.H603. PMID   2923227.
  25. ↑ Noji T, Nan-ya K, Mizutani M, Katagiri C, Sano J, Takada C, Nishikawa S, Karasawa A, Kusaka H (2002). "KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice". Eur J Pharmacol. 454 (1): 85–93. doi:10.1016/S0014-2999(02)02476-7. PMID   12409009.
  26. ↑ Lee CM, Cheung WT (1985). "Inhibitory effect of adenosine on electrically evoked contractions in the rat vas deferens: pharmacological characterization". Neurosci Lett. 59 (1): 47–52. doi:10.1016/0304-3940(85)90213-7. PMID   2995881. S2CID   42019444.
  27. ↑ Marangos PJ, Patel J, Clark-Rosenberg R, Martino AM (1982). "[3H]nitrobenzylthioinosine binding as a probe for the study of adenosine uptake sites in brain". J. Neurochem. 39 (1): 184–191. doi:10.1111/j.1471-4159.1982.tb04717.x. PMID   7086410. S2CID   25920625.
  28. ↑ Coffin VL, Taylor JA, Phillis JW, Altman HJ, Barraco RA (1984). "Behavioral interaction of adenosine and methylxanthines on central purinergic systems". Neurosci Lett. 47 (2): 91–98. doi:10.1016/0304-3940(84)90412-9. PMID   6205333. S2CID   19628381.
  29. ↑ Shi D, Daly JW (1999). "Chronic effects of xanthines on levels of central receptors in mice". Cell Mol Neurobiol. 19 (6): 719–732. doi:10.1023/A:1006901005925. PMC   11545639 . PMID   10456233. S2CID   10644334.
  30. ↑ Phillis J.W. (1985). "Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons". Gen Pharmacol. 16 (1): 19–24. doi:10.1016/0306-3623(85)90264-2. PMID   2984085.
  31. ↑ Phillis J.W. (1984). "Interactions of the anticonvulsants diphenylhydantoin and carbamazepine with adenosine on cerebral cortical neurons". Epilepsia. 25 (6): 765–772. doi:10.1111/j.1528-1157.1984.tb03489.x. PMID   6510384. S2CID   30358234.
  32. ↑ Andiné P, Rudolphi KA, Fredholm BB, Hagberg H (1990). "Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia". Br J Pharmacol. 100 (4): 814–818. doi:10.1111/j.1476-5381.1990.tb14097.x. PMC   1917600 . PMID   2207501.
  33. ↑ Ohmori H, Sato Y, Namiki A (2004). "The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices". Anesth Analg. 99 (4): 1095–1101. doi: 10.1213/01.ANE.0000130356.22414.2B . PMID   15385357.
  34. ↑ Noji T, Nan-ya K, Katagiri C, Mizutani M, Sano J, Nishikawa S, Karasawa A, Kusaka H (2002). "Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice". Pancreas. 25 (4): 387–392. doi:10.1097/00006676-200211000-00011. PMID   12409834. S2CID   24260175.
  35. ↑ Gresele P, Arnout J, Deckmyn H, Vermylen J (1986). "Mechanism of the antiplatelet action of dipyridamole in whole blood: modulation of adenosine concentration and activity". Thromb Haemost. 55 (1): 12–18. doi:10.1055/s-0038-1661437. PMID   3704998. S2CID   7318055.
  36. ↑ Bauman LA, Mahle CD, Boissard CG, Gribkoff VK (1992). "Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices". J Neurophysiol. 68 (2): 629–638. doi:10.1152/jn.1992.68.2.629. PMID   1388201.
  37. ↑ Boissard CG, Gribkoff VK (1993). "The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro". Neuropharmacology. 32 (2): 149–155. doi:10.1016/0028-3908(93)90095-K. PMID   8383814. S2CID   10716297.
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