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Clinical data | |
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Other names | N6-[(S)-1-(Phenyl)propyl]adenosine |
Drug class | Adenosine receptor agonist; Sedative; Hypnotic |
ATC code |
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PubChem CID | |
Chemical and physical data | |
Formula | C19H23N5O4 |
Molar mass | 385.424 g·mol−1 |
3D model (JSmol) | |
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YZG-331, also known as N6-[(S)-1-(phenyl)propyl]adenosine, is an adenosine receptor agonist which is or was under investigation for the potential treatment of insomnia. [1] [2] [3]
The drug appears to act through the adenosine A1 and A2A receptors. [3] It produces sedative and hypnotic effects and hypolocomotion in animals. [3] The drug is orally active and crosses the blood–brain barrier, although its intestinal absorption and central permeability may be reduced by its P-glycoprotein substrate activity. [4] [5] It is a synthetic derivative of adenosine and of N6-(4-hydroxybenzyl)adenine riboside (NHBA). [5] [3] The latter compound is found in the traditional Chinese medicinal herb Gastrodia elata . [5] [3]
YZG-331 was first described in the scientific literature by at least 2014. [6] As of 2025, it has reached the preclinical research stage of development. [1]
1. Adenosine Receptor Agonist. YZG-331 is a promising sedative hypnotic and adenosine analog that exerts its effects by binding to the adenosine receptor. (See the Other Receptors section for a review of the pharmacology of A1A and A2A.)