Homatropine methylbromide

Last updated
Homatropine methylbromide
Methylhomatropine bromide.svg
Clinical data
Other namesMethylhomatropine bromide
ATC code
Identifiers
  • (N,N-Dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate bromide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.001.168 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C17H24BrNO3
Molar mass 370.287 g·mol−1
3D model (JSmol)
  • C[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]
  • InChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1/t13-,14+,15+,16?; Yes check.svgY
  • Key:ZTVIKZXZYLEVOL-MCOXGKPRSA-N Yes check.svgY
   (verify)

Homatropine methylbromide (INN; also known as methylhomatropine bromide) is a quaternary ammonium salt of methylhomatropine. It is a peripherally acting anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It does not cross the blood–brain barrier. It is used to effectively relieve intestinal spasms and abdominal cramps, without producing the adverse effects of less specific anticholinergics. [1] It is used, in addition to papaverine, as a component of mild drugs that help "flush" the bile.

Contents

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-therapeutic amount of homatropine methylbromide to discourage intentional overdose. [2]

Contraindications

See also

References

  1. ↑ "Paratropina (Homatropine Methylbromide)". Archived from the original on 2017-04-29. Retrieved 2016-02-18.
  2. ↑ "Hydromet (Hydrocodone Bitartrate and Homatropine Methylbromide)". DailyMed. NIH.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.