Metixene

Metixene
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N04AA03 ( WHO );
Legal status
Legal status	BR: Class C1 (Other controlled substances);
Identifiers
	IUPAC name 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine;
CAS Number	4969-02-2 ;
PubChem CID	4167 ;
IUPHAR/BPS	7232 ;
DrugBank	DB00340 ;
ChemSpider	4023 ;
UNII	32VY6L26ZW ;
KEGG	D08209 ;
ChEBI	CHEBI:51024 ;
ChEMBL	ChEMBL1201342 ;
CompTox Dashboard (EPA)	DTXSID1047867 ;
ECHA InfoCard	100.023.282
Chemical and physical data
Formula	C20H23NS
Molar mass	309.47 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24;
	InChI InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3; Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N;
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Last updated September 13, 2025

Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent.^[2] It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases. ^[3]

References

↑ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
↑ Morton IK, Hall JM (1999). "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178. ISBN 978-94-011-4439-1.
↑ Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. 133 (24) e161142. doi: 10.1172/JCI161142 . PMC 10721147 . PMID 37847564.

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[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Morton IK, Hall JM (1999). "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178. ISBN 978-94-011-4439-1.

[3] Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. 133 (24) e161142. doi: 10.1172/JCI161142 . PMC 10721147 . PMID 37847564.

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Metixene

See also

References