Adenosine receptor antagonist

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An adenosine receptor antagonist is a drug which acts as an antagonist of one or more of the adenosine receptors. [1] The best known are xanthines and their derivatives (natural: caffeine, [2] theophylline, [3] and theobromine; and synthetic: PSB-1901 [4] ), but there are also non-xanthine representatives (e.g. ISAM-140, [5] ISAM-R316, [6] etrumadenant, [7] and AZD-4635 [8] )

See also

References

  1. ↑ Müller, CE; Jacobson, KA (2011). Xanthines as adenosine receptor antagonists. Handbook of Experimental Pharmacology. Vol. 200. pp. 151–99. doi:10.1007/978-3-642-13443-2_6. ISBN   978-3-642-13442-5. PMC   3882893 . PMID   20859796.
  2. ↑ Rivera-Oliver, Marla; Díaz-Ríos, Manuel (April 2014). "Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review". Life Sciences. 101 (1–2): 1–9. doi:10.1016/j.lfs.2014.01.083. PMC   4115368 . PMID   24530739.
  3. ↑ Hauber, W.; Muenkle, M. (July 1996). "The adenosine receptor antagonist theophylline induces a monoamine-dependent increase of the anticataleptic effects of NMDA receptor antagonists". Naunyn-Schmiedeberg's Archives of Pharmacology. 354 (2): 179–186. doi:10.1007/BF00178718. PMID   8857595. S2CID   21765941.
  4. ↑ Jiang, Jie; Seel, Catharina Julia; Temirak, Ahmed; Namasivayam, Vigneshwaran; Arridu, Antonella; Schabikowski, Jakub; Baqi, Younis; Hinz, Sonja; Hockemeyer, Jörg; Müller, Christa E. (2019-04-25). "A2B Adenosine Receptor Antagonists with Picomolar Potency". Journal of Medicinal Chemistry. 62 (8): 4032–4055. doi:10.1021/acs.jmedchem.9b00071. ISSN   1520-4804. PMID   30835463. S2CID   73472174.
  5. ↑ El Maatougui, Abdelaziz; Azuaje, Jhonny; González-Gómez, Manuel; Miguez, Gabriel; Crespo, Abel; Carbajales, Carlos; Escalante, Luz; García-Mera, Xerardo; Gutiérrez-de-Terán, Hugo; Sotelo, Eddy (2016-03-10). "Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes". Journal of Medicinal Chemistry. 59 (5): 1967–1983. doi:10.1021/acs.jmedchem.5b01586. ISSN   1520-4804. PMID   26824742.
  6. ↑ Prieto-Díaz, Rubén; González-Gómez, Manuel; Fojo-Carballo, Hugo; Azuaje, Jhonny; El Maatougui, Abdelaziz; Majellaro, Maria; Loza, María I.; Brea, José; Fernández-Dueñas, Víctor; Paleo, M. Rita; Díaz-Holguín, Alejandro; Garcia-Pinel, Beatriz; Mallo-Abreu, Ana; Estévez, Juan C.; Andújar-Arias, Antonio (2022-12-14). "Exploring the Effect of Halogenation in a Series of Potent and Selective A 2B Adenosine Receptor Antagonists". Journal of Medicinal Chemistry. 66 (1): 890–912. doi:10.1021/acs.jmedchem.2c01768. ISSN   0022-2623. PMC   9841532 . PMID   36517209. S2CID   254759241.
  7. ↑ PubChem. "3-(2-Amino-6-(1-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl)-2-methylbenzonitrile". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-08-27.
  8. ↑ Borodovsky, Alexandra; Barbon, Christine M.; Wang, Yanjun; Ye, Minwei; Prickett, Laura; Chandra, Dinesh; Shaw, Joseph; Deng, Nanhua; Sachsenmeier, Kris; Clarke, James D.; Linghu, Bolan; Brown, Giles A.; Brown, James; Congreve, Miles; Cheng, Robert Ky (July 2020). "Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity". Journal for Immunotherapy of Cancer. 8 (2): e000417. doi:10.1136/jitc-2019-000417. ISSN   2051-1426. PMC   7394305 . PMID   32727810.


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