ABT-670

ABT-670
Identifiers
	IUPAC name 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide;
CAS Number	630119-43-6 ;
PubChem CID	16094676 ;
ChemSpider	17252978 ;
UNII	4L6071XH2J ;
ChEMBL	ChEMBL219182 ;
CompTox Dashboard (EPA)	DTXSID30212235 ;
Chemical and physical data
Formula	C19H23N3O2
Molar mass	325.412 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C;
	InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23) ; Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N ;
	(what is this?) (verify)

Last updated June 07, 2025

ABT-670 is a drug which acts as a potent, orally bioavailable dopamine agonist selective for the D₄ subtype, which was developed as a possible treatment for erectile dysfunction,^[1] although its current uses are limited to scientific research.^[2]

References

↑ Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. (December 2006). "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction". Journal of Medicinal Chemistry. 49 (25): 7450–65. doi:10.1021/jm060662k. PMID 17149874.
↑ Richards N, Wayman C, Allers KA (November 2009). "Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection". Neuroscience Letters. 465 (3): 242–7. doi:10.1016/j.neulet.2009.08.078. PMID 19733217. S2CID 27767274.

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[1] Patel MV, Kolasa T, Mortell K, Matulenko MA, Hakeem AA, Rohde JJ, et al. (December 2006). "Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction". Journal of Medicinal Chemistry. 49 (25): 7450–65. doi:10.1021/jm060662k. PMID 17149874.

[pmid19733217-2] Richards N, Wayman C, Allers KA (November 2009). "Electrophysiological actions of the dopamine agonist apomorphine in the paraventricular nucleus during penile erection". Neuroscience Letters. 465 (3): 242–7. doi:10.1016/j.neulet.2009.08.078. PMID 19733217. S2CID 27767274.

[1]

[2]

Identifiers

IUPAC name 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide
CAS Number	630119-43-6 ^N
PubChem CID	16094676
ChemSpider	17252978 ^Y
UNII	4L6071XH2J
ChEMBL	ChEMBL219182 ^Y
CompTox Dashboard (EPA)	DTXSID30212235
Chemical and physical data
Formula	C₁₉H₂₃N₃O₂
Molar mass	325.412 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [O-][n+]1ccccc1C(CC3)CCN3CNC(=O)c(c2)cccc2C
InChI InChI=1S/C19H23N3O2/c1-15-5-4-6-17(13-15)19(23)20-14-21-11-8-16(9-12-21)18-7-2-3-10-22(18)24/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,20,23)^Y Key:PUMMPCXNEPHBNN-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

ABT-670

See also

References