UK-414,495

Last updated

UK-414,495
UK-414,495.svg
Identifiers
  • (2R)-2-({1-[(5-ethyl-1,3,4-thiadiazol-2-yl)carbamoyl]cyclopentyl}methyl)pentanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C16H25N3O3S
Molar mass 339.45 g·mol−1
3D model (JSmol)
  • CCC[C@H](CC1(CCCC1)C(=O)NC2=NN=C(S2)CC)C(=O)O
  • InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 X mark.svgN
  • Key:FWXXCSISWQQOGS-LLVKDONJSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder. UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP. The consequent increase in VIP activity alters blood flow to the genital region leading to increased lubrication and muscle relaxation. [1] [2] [3]

See also

References

  1. ↑ Armer R, Warne P, Witherington J (2006). "Recent disclosures of clinical drug candidates". Drug News & Perspectives. 19 (1): 65–72. PMID   16550257.
  2. ↑ Angulo J (May 2010). "Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?". British Journal of Pharmacology. 160 (1): 48–50. doi:10.1111/j.1476-5381.2010.00693.x. PMC   2860205 . PMID   20412067.
  3. ↑ Wayman CP, Baxter D, Turner L, Van Der Graaf PH, Naylor AM (May 2010). "UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit". British Journal of Pharmacology. 160 (1): 51–59. doi:10.1111/j.1476-5381.2010.00691.x. PMC   2860206 . PMID   20412068.
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