S-17092

Last updated
S-17092
S-17092.svg
Legal status
Legal status
Identifiers
  • [(2S,3aS,7aS)-1([(R,R)-2-phenylcyclopropyl]- carbonyl)-2-([thiazolidin-3-yl]carbonyl)octahydro-1H-indole
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C23H29FN2O2
Molar mass 384.495 g·mol−1
3D model (JSmol)
  • O=C(N1CCCC1)[C@H]4N(C(=O)[C@H]3[C@H](c2ccc(F)cc2)C3)[C@H]5CCCC[C@H]5C4
  • InChI=1S/C23H29FN2O2/c24-17-9-7-15(8-10-17)18-14-19(18)22(27)26-20-6-2-1-5-16(20)13-21(26)23(28)25-11-3-4-12-25/h7-10,16,18-21H,1-6,11-14H2/t16-,18-,19+,20-,21-/m0/s1 X mark.svgN
  • Key:JNUXCIMICQKTPX-RQUKQETFSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

S-17092 is a drug which acts as a selective inhibitor of the enzyme prolyl endopeptidase. [1] This enzyme is involved in the metabolic breakdown of a number of neuropeptide neurotransmitters in the brain, [2] [3] and so inhibiting the action of the enzyme increases the activity of these neuropeptides. This produces nootropic effects which make S-17092 a promising and novel treatment for neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease. [4] [5]

See also

References

  1. ↑ Barelli H, Petit A, Hirsch E, Wilk S, De Nanteuil G, Morain P, Checler F (April 1999). "S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase". Biochemical and Biophysical Research Communications. 257 (3): 657–61. Bibcode:1999BBRC..257..657B. doi:10.1006/bbrc.1999.0366. PMID   10208839.
  2. ↑ Bellemère G, Morain P, Vaudry H, Jégou S (March 2003). "Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain". Journal of Neurochemistry. 84 (5): 919–29. doi:10.1046/j.1471-4159.2003.01536.x. PMID   12603817. S2CID   24773419.
  3. ↑ Bellemère G, Vaudry H, Morain P, Jégou S (May 2005). "Effect of prolyl endopeptidase inhibition on arginine-vasopressin and thyrotrophin-releasing hormone catabolism in the rat brain". Journal of Neuroendocrinology. 17 (5): 306–13. doi:10.1111/j.1365-2826.2005.01308.x. PMID   15869566. S2CID   9129184.
  4. ↑ Morain P, Lestage P, De Nanteuil G, Jochemsen R, Robin JL, Guez D, Boyer PA (2002). "S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies". CNS Drug Reviews. 8 (1): 31–52. doi:10.1111/j.1527-3458.2002.tb00214.x. PMC   6741683 . PMID   12070525.
  5. ↑ Morain P, Boeijinga PH, Demazières A, De Nanteuil G, Luthringer R (2007). "Psychotropic profile of S 17092, a prolyl endopeptidase inhibitor, using quantitative EEG in young healthy volunteers". Neuropsychobiology. 55 (3–4): 176–83. doi:10.1159/000107070. PMID   17700042. S2CID   27856130.


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