Desmethoxyfallypride

Desmethoxyfallypride (¹⁸F)
Clinical data
Other names	DMFP (18F)
ATC code	none;
Identifiers
	IUPAC name 5-(3-fluoropropyl)-2-methoxy-N-[[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide;
CAS Number	166173-81-5 ;
PubChem CID	10404663 ;
ChemSpider	8580101 ;
UNII	CJD4EF9EME ;
ChEMBL	ChEMBL428561 ;
Chemical and physical data
Formula	C19H27FN2O2
Molar mass	334.435 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES COC1=C(C=C(C=C1)CCCF)C(=O)NC[C@@H]2CCCN2CC=C;
	InChI InChI=1S/C19H27FN2O2/c1-3-11-22-12-5-7-16(22)14-21-19(23)17-13-15(6-4-10-20)8-9-18(17)24-2/h3,8-9,13,16H,1,4-7,10-12,14H2,2H3,(H,21,23)/t16-/m0/s1; Key:VPBJNBUDASILSQ-INIZCTEOSA-N;

Last updated June 01, 2025

Desmethoxyfallypride is a moderate affinity dopamine D₂ receptor/D₃ receptor antagonist used in medical research, usually in the form of the radiopharmaceutical [F-18]-desmethoxyfallypride (DMFP(¹⁸F))^[1]^[2] which has been used in human studies as a positron emission tomography (PET) radiotracer.^[3]^[4]

References

↑ Mukherjee J, Yang ZY, Brown T, Roemer J, Cooper M (1996). "18F-desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors". Life Sciences. 59 (8): 669–78. doi:10.1016/0024-3205(96)00348-7. PMID 8761017.
↑ Leung, K. (2004). "(S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-[¹⁸F]fluoropropyl)-2-methoxybenzamide". Molecular Imaging and Contrast Agent Database. PMID 20641474.
↑ Gründer G, Siessmeier T, Piel M, Vernaleken I, Buchholz HG, Zhou Y, et al. (January 2003). "Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride". Journal of Nuclear Medicine. 44 (1): 109–16. PMID 12515884.
↑ Siessmeier T, Zhou Y, Buchholz HG, Landvogt C, Vernaleken I, Piel M, et al. (June 2005). "Parametric mapping of binding in human brain of D2 receptor ligands of different affinities". Journal of Nuclear Medicine. 46 (6): 964–72. PMID 15937307.

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[1] Mukherjee J, Yang ZY, Brown T, Roemer J, Cooper M (1996). "18F-desmethoxyfallypride: a fluorine-18 labeled radiotracer with properties similar to carbon-11 raclopride for PET imaging studies of dopamine D2 receptors". Life Sciences. 59 (8): 669–78. doi:10.1016/0024-3205(96)00348-7. PMID 8761017.

[2] Leung, K. (2004). "(S)-N-((1-Allyl-2-pyrrolidinyl)methyl)-5-(3-[¹⁸F]fluoropropyl)-2-methoxybenzamide". Molecular Imaging and Contrast Agent Database. PMID 20641474.

[3] Gründer G, Siessmeier T, Piel M, Vernaleken I, Buchholz HG, Zhou Y, et al. (January 2003). "Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride". Journal of Nuclear Medicine. 44 (1): 109–16. PMID 12515884.

[4] Siessmeier T, Zhou Y, Buchholz HG, Landvogt C, Vernaleken I, Piel M, et al. (June 2005). "Parametric mapping of binding in human brain of D2 receptor ligands of different affinities". Journal of Nuclear Medicine. 46 (6): 964–72. PMID 15937307.

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