Morazone

Morazone

Clinical data
Routes of administration	Oral, SC, IM [1]
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 1,5-dimethyl-4-[(3-methyl-2-phenylmorpholin-4-yl)methyl]-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
CAS Number	6536-18-1  N
PubChem CID	39609
ChemSpider	36216  Y
UNII	870Q5BL2FN
CompTox Dashboard (EPA)	DTXSID10863901
ECHA InfoCard	100.026.771
Chemical and physical data
Formula	C23H27N3O2
Molar mass	377.488 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1ccccc1N2N(C)C(C)=C(C2=O)CN3CCOC(C3C)c4ccccc4
InChI InChI=1S/C23H27N3O2/c1-17-21(23(27)26(24(17)3)20-12-8-5-9-13-20)16-25-14-15-28-22(18(25)2)19-10-6-4-7-11-19/h4-13,18,22H,14-16H2,1-3H3 Y Key:OOGNFQMTGRZRAB-UHFFFAOYSA-N Y
NY  (what is this?)    (verify)

Morazone (Novartrina, Orsimon, Rosimon-Neu, Tarcuzate) is a nonsteroidal anti-inflammatory drug (NSAID), originally developed by the German pharmaceutical company Ravensberg in the 1950s, which is used as an analgesic. ^{[1] [2] [3]} It produces phenmetrazine as a major metabolite and has been reported to have been abused as a recreational drug in the past. ^{[4] [5] [6] [7]}

See also

• Famprofazone
• Morforex

References

1. Seyffart G (1991). Drug dosage in Renal Insufficiency. Boston: Kluwer Academic Publishers. p. 399. ISBN   978-0-7923-0964-2.
2. USpatent 2943022,Siemer, H.&Doppstadt, A.,"Substituted 1-phenyl-2,3-dimethyl-4-morpholino methyl pyrazolone-(5) Compounds and Process of Making Same",issued 1960-06-28, assigned to Ravensberg 
3. Buckingham J, ed. (1996). Dictionary of Organic Compounds. Vol. 7. London: Chapman & Hall. p. 4659. ISBN   978-0-412-54090-5.
4. Bohn G, Rücker G, Kröger H (June 1976). "[Investigations of the decomposition and detection of morazone by thin-layer- and gas-liquid-chromatography]". Archives of Toxicology. 35 (3): 213–20. doi:10.1007/bf00293569. PMID   989292. S2CID   23956851.
5. Neugebauer M (1984). "Some new urinary metabolites of famprofazone and morazone in man". Journal of Pharmaceutical and Biomedical Analysis. 2 (1): 53–60. doi:10.1016/0731-7085(84)80089-8. PMID   16867765.
6. Kingreen JC, Breger G (May 1984). "[Pellagra in morazone abuse]". Zeitschrift für Hautkrankheiten. 59 (9): 573–7. PMID   6145264.
7. Daunderer M, Janzen W (1972). "[ROSIMON-NEU--a non-prescription analgesic on the adolescent drug scene]". Beiträge zur Gerichtlichen Medizin. 29: 138–43. PMID   5081964.