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| Formula | C38H50F2N2O3 |
| Molar mass | 620.826 g·mol−1 |
| 3D model (JSmol) | |
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DBL-583 is a selective dopamine reuptake inhibitor of the piperazine chemical class. [1] It is the decanoate ester of a hydroxy vanoxerine. [1] DBL-583 breaks down very slowly in the body, lasting for up to a month after a single injection. [1]
Typical antipsychotics are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis. Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions. The first typical antipsychotics to come into medical use were the phenothiazines, namely chlorpromazine which was discovered serendipitously. Another prominent grouping of antipsychotics are the butyrophenones, an example of which is haloperidol. The newer, second-generation antipsychotics, also known as atypical antipsychotics, have largely supplanted the use of typical antipsychotics as first-line agents due to the higher risk of movement disorders in the latter.
A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron. This results in increased extracellular concentrations of dopamine and increase in dopaminergic neurotransmission.
Nandrolone, also known as 19-nortestosterone, is an androgen and anabolic steroid (AAS) which is used in the form of esters such as nandrolone decanoate and nandrolone phenylpropionate. Nandrolone esters are used in the treatment of anemias, cachexia, osteoporosis, breast cancer, and for other indications. They are not used by mouth and instead are given by injection into muscle or fat.
Nandrolone decanoate, sold under the brand name Deca-Durabolin among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemias and wasting syndromes, as well as osteoporosis in menopausal women. It is given by injection into muscle or fat once every one to four weeks.
José Luis González Sánchez is a Spanish former middle-distance runner. He represented Spain at the Olympics on three occasions with his best performance being a semi-final run in the 1500 m in 1980.
Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor (DRI). GBR-12909 binds to the target site on the dopamine transporter (DAT) ~ 50 times more strongly than cocaine, but simultaneously inhibits the release of dopamine. This combined effect only slightly elevates dopamine levels, giving vanoxerine only mild stimulant effects. Vanoxerine has also been observed to be a potent blocker of the IKr (hERG) channel. GBR-12909 also binds with nanomolar affinity to the serotonin transporter.
The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane, with any number of attached substituents, including bridges. This group typically excludes compounds in which either benzene is fused to another ring or includes a heteroatom, or where the methane connects to three or four benzenes.
Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.
Donar, also known as Donar Groningen, is a professional basketball club based in Groningen, Netherlands. The club competes in the Dutch Basketball League (DBL) and its home arena is MartiniPlaza, which has a seating capacity of 4,350 people. Due to sponsorship reasons the club was also known as GasTerra Flames and Capitals during the 2000s.
GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain.
Landstede Hammers is a Dutch basketball club based in Zwolle. The club currently plays in the Dutch Basketball League (DBL), the Dutch top tier division. The club was founded as Cees Lubbers The Hammers in 1995. In 1999, the club’s name was changed into Landstede Hammers. In 2001, the club received its current name Landstede Basketbal. The home games of the club are played in the Landstede Sportcentrum.
Feyenoord Basketball is a Dutch professional basketball club based in Rotterdam. The team plays in the Dutch Basketball League (DBL) and plays its home games at the Topsportcentrum next to De Kuip in Rotterdam. It is the basketball section of the football club Feyenoord.
GBR-12783 is a psychostimulant which acts as a selective dopamine reuptake inhibitor.
GBR-13069 is a psychostimulant and selective dopamine reuptake inhibitor.
GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.
GBR-13119 is a psychostimulant and dopamine re-uptake inhibitor.
The DBL Play-offs MVP is an annual Dutch Basketball League award given since to the league's most valuable player in the Playoffs of a given DBL season. The award was handed out for the first time in the 2004–05 season, but after then the award disappeared. In the 2013–14 season, the award would be handed out again.
BV Den Helder was a professional basketball club from Den Helder, Netherlands. The team had several seasons in the Dutch Basketball League, the highest professional league in the Netherlands. The club is currently inactive, however Den Helder Suns has replaced the club as professional team from Den Helder.
Testosterone propionate/testosterone phenylpropionate/testosterone isocaproate/testosterone caproate (TP/TPP/TiC/TCa), sold under the brand name Omnadren or Omnadren 250, is an injectable combination medication of four testosterone esters, all of which are androgens/anabolic steroids, which is no longer marketed. Its constituents included:
Nandrolone phenylpropionate (NPP), or nandrolone phenpropionate, sold under the brand name Durabolin among others, is an androgen and anabolic steroid (AAS) medication which has been used primarily in the treatment of breast cancer and osteoporosis in women. It is given by injection into muscle once every week. Although it was widely used in the past, the drug has mostly been discontinued and hence is now mostly no longer available.
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