Tricyclic

For the plant morphology term, see Tricyclic flower.

Dibenzazepine

Phenothiazine

Tricyclics are cyclic chemical compounds that contain three fused rings of atoms.

Many compounds have a tricyclic structure, but in pharmacology, the term has traditionally been reserved to describe heterocyclic drugs. They include antidepressants, antipsychotics, anticonvulsants, and antihistamines (as antiallergens, anti-motion sickness drugs, antipruritics, and hypnotics/sedatives) of the dibenzazepine, dibenzocycloheptene, dibenzothiazepine, dibenzothiepin, phenothiazine, and thioxanthene chemical classes, and others.

History

• Promethazine and other first generation antihistamines with a tricyclic structure were discovered in the 1940s.
• Chlorpromazine, derived from promethazine originally as a sedative, was found to have neuroleptic properties in the early 1950s, and was the first typical antipsychotic.
• Imipramine, originally investigated as an antipsychotic, was discovered in the early 1950s, and was the first tricyclic antidepressant.
• Carbamazepine was discovered in 1953, and was subsequently introduced as an anticonvulsant in 1965.
• Clozapine, a derivative of imipramine, was synthesized in 1958 and entered the European market in 1972 under the name Leponex.
• Antidepressants with a tetracyclic structure such as mianserin and maprotiline were first developed in the 1970s as tetracyclic antidepressants.
• Loratadine was introduced as a non-sedating second generation antihistamine in the 1990s. ^[1]

Gallery

Antidepressants
Imipramine	Amitriptyline	Iprindole	Tianeptine	Doxepin
Antipsychotics
Chlorpromazine	Thioridazine	Chlorprothixene	Loxapine	Clozapine
Antihistamines
Promethazine	Cyproheptadine	Latrepirdine	Loratadine	Rupatadine
Others
Carbamazepine	Carvedilol		Cyclobenzaprine	Pizotifen

See also

• Bisulepin
• Tetracyclic
• Tricyclic tropane analogs
• Heterocyclic

References

1. Kay, G. G.; Harris, A. G. (1999). "Loratadine: a non-sedating antihistamine. Review of its effects on cognition, psychomotor performance, mood and sedation". Clinical and Experimental Allergy. 29 Suppl 3: 147–150. doi:10.1046/j.1365-2222.1999.0290s3147.x. PMID   10444229.