Ketipramine

Last updated
Ketipramine
Ketipramine.png
Clinical data
Routes of
administration 		Oral
ATC code
  • none
Identifiers
  • 5-[3-(dimethylamino)propyl]-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C19H22N2O
Molar mass 294.398 g·mol−1
3D model (JSmol)
  • O=C3c1c(cccc1)N(c2c(cccc2)C3)CCCN(C)C

Ketipramine (G-35,259), also known as ketimipramine or ketoimipramine, is a tricyclic antidepressant (TCA) that was tested in clinical trials for the treatment of depression in the 1960s but was never marketed. [1] [2] [3] It differs from imipramine in terms of chemical structure only by a single ketone group, and is approximately equivalent in effectiveness as an antidepressant in comparison. [4]

It was one of the drugs tested by Roland Kuhn in a series of unethical experiments testing drugs on children without informed consent that were done in a psychiatric hospital located in Münsterlingen, Switzerland. [5] [6] [7]

See also

References

  1. ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN   0-412-54090-8.
  2. ↑ Simeon J, Fuchs M, Nikolovski O, Bucci L (1970). "Ketipramine in the therapy of depression in outpatients". Psychosomatics. 11 (4): 342–6. doi:10.1016/S0033-3182(70)71634-4. PMID   5459338. Archived from the original on 2011-07-27.
  3. ↑ Park S, Glick B, Floyd A, Gershon S (May 1971). "Ketipramine fumarate as compared to imipramine in depressed outpatients". Current Therapeutic Research, Clinical and Experimental. 13 (5): 322–5. PMID   4998396.
  4. ↑ Author Unknown (1971). Ann Reports Medicinal Chem V6 (v. 6). Boston: Academic Press. ISBN   0-12-040506-7.{{cite book}}: |author= has generic name (help)
  5. ↑ Die Experimente von Münsterlingen 20. November 2012. Tages-Anzeiger
  6. ↑ Münsterlingen: Alles noch viel schlimmer
  7. ↑ Simone Rau: Das Ausmass der Medi-Versuche in Münsterlingen ist weit grösser. In: Der Bund , 31. Oktober 2016.
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